Altered fornix integrity is associated with sleep apnea-related hypoxemia in mild cognitive impairment.

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State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_7A896025EA20
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Altered fornix integrity is associated with sleep apnea-related hypoxemia in mild cognitive impairment.
Journal
Alzheimer's & dementia
Author(s)
Marchi N.A., Daneault V., André C., Martineau-Dussault M.È., Baril A.A., Thompson C., Montplaisir J.Y., Gilbert D., Lorrain D., Boré A., Descoteaux M., Carrier J., Gosselin N.
ISSN
1552-5279 (Electronic)
ISSN-L
1552-5260
Publication state
Published
Issued date
06/2024
Peer-reviewed
Oui
Volume
20
Number
6
Pages
4092-4105
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The limbic system is critical for memory function and degenerates early in the Alzheimer's disease continuum. Whether obstructive sleep apnea (OSA) is associated with alterations in the limbic white matter tracts remains understudied.
Polysomnography, neurocognitive assessment, and brain magnetic resonance imaging (MRI) were performed in 126 individuals aged 55-86 years, including 70 cognitively unimpaired participants and 56 participants with mild cognitive impairment (MCI). OSA measures of interest were the apnea-hypopnea index and composite variables of sleep fragmentation and hypoxemia. Microstructural properties of the cingulum, fornix, and uncinate fasciculus were estimated using free water-corrected diffusion tensor imaging.
Higher levels of OSA-related hypoxemia were associated with higher left fornix diffusivities only in participants with MCI. Microstructure of the other white matter tracts was not associated with OSA measures. Higher left fornix diffusivities correlated with poorer episodic verbal memory.
OSA may contribute to fornix damage and memory dysfunction in MCI.
Sleep apnea-related hypoxemia was associated with altered fornix integrity in MCI. Altered fornix integrity correlated with poorer memory function. Sleep apnea may contribute to fornix damage and memory dysfunction in MCI.
Keywords
Humans, Male, Female, Cognitive Dysfunction/etiology, Aged, Fornix, Brain/diagnostic imaging, Fornix, Brain/pathology, Middle Aged, Aged, 80 and over, Hypoxia/complications, Diffusion Tensor Imaging, Polysomnography, Neuropsychological Tests/statistics & numerical data, White Matter/diagnostic imaging, White Matter/pathology, Magnetic Resonance Imaging, Sleep Apnea Syndromes/complications, Sleep Apnea, Obstructive/complications, Alzheimer's disease, dementia, fornix, free water‐diffusion tensor imaging, hypoxia, limbic system, memory, mild cognitive impairment, sleep, sleep apnea, white matter
Pubmed
Web of science
Open Access
Yes
Create date
10/05/2024 14:18
Last modification date
22/06/2024 6:07
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