Méta-analyses d'essais randomisés sur données individuelles dans le traitement des cancers ORL non métastatiques : principes, résultats, perspectives [Individual patient data meta-analyses of randomized trials for the treatment of non-metastatic head and neck squamous cell carcinomas: Principles, results and perspectives].

Details

Serval ID
serval:BIB_7A5B3B569B28
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Méta-analyses d'essais randomisés sur données individuelles dans le traitement des cancers ORL non métastatiques : principes, résultats, perspectives [Individual patient data meta-analyses of randomized trials for the treatment of non-metastatic head and neck squamous cell carcinomas: Principles, results and perspectives].
Journal
Cancer Radiothérapie
Author(s)
Blanchard P., Bourhis J., Lacas B., Le Teuff G., Michiels S., Pignon J.P.
ISSN
1769-6658 (Electronic)
ISSN-L
1278-3218
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
19
Number
3
Pages
198-204
Language
french
Notes
Publication types: English Abstract ; Journal Article Publication Status: ppublish
Abstract
Meta-analyses are considered as an important pillar of evidence-based medicine. The aim of this review is to describe the main principles of a meta-analysis and to use examples of head and neck oncology to demonstrate their clinical impact and methodological interest. The major role of individual patient data is outlined, as well as the superiority of individual patient data over meta-analyses based on published summary data. The major clinical breakthrough of head and neck meta-analyses are summarized, regarding concomitant chemotherapy, altered fractionated chemotherapy, new regimens of induction chemotherapy or the use of radioprotectants. Recent methodological developments are described, including network meta-analyses, the validation of surrogate markers. Lastly, the future of meta-analyses is discussed in the context of personalized medicine.
Pubmed
Web of science
Create date
29/06/2015 14:06
Last modification date
20/08/2019 15:36
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