Linking inflammasome activation and phagosome maturation.

Details

Serval ID
serval:BIB_7A2FB72C2BDC
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Title
Linking inflammasome activation and phagosome maturation.
Journal
Cell Host and Microbe
Author(s)
Lazarevic V., Martinon F.
ISSN
1934-6069 (Electronic)
ISSN-L
1931-3128
Publication state
Published
Issued date
2008
Volume
3
Number
4
Pages
199-200
Language
english
Abstract
One-third of the world's population is infected with Mycobacterium tuberculosis, one of the most effective human pathogens, whose success is attributed to the deployment of remarkably sophisticated immune evasion mechanisms. In this issue of Cell Host & Microbe, a new study unravels a novel strategy of immune evasion and enhanced bacterial intracellular survival, which is dependent on inhibition of inflammasome activation by an M. tuberculosis-encoded metalloprotease.
Keywords
Animals, Apoptosis Regulatory Proteins/metabolism, Bacterial Infections/immunology, CARD Signaling Adaptor Proteins/metabolism, Calcium-Binding Proteins/metabolism, Cell Differentiation, Cytoskeletal Proteins/metabolism, Down-Regulation, Host-Pathogen Interactions/immunology, Humans, Immunity, Innate/immunology, Inflammation/immunology, Interleukin-1beta/metabolism, Macrophages/cytology, Macrophages/metabolism, Metalloproteases/metabolism, Mycobacterium tuberculosis/enzymology, Mycobacterium tuberculosis/pathogenicity, Phagosomes/metabolism, Receptors, Interleukin-1/physiology, Signal Transduction, Tuberculosis/immunology
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2011 15:36
Last modification date
20/08/2019 14:36
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