Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity

Details

Serval ID
serval:BIB_793399AA8E06
Type
Article: article from journal or magazin.
Collection
Publications
Title
Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
Journal
International Journal of Obesity and Related Metabolic Disorders
Author(s)
Clement  K., Ruiz  J., Cassard-Doulcier  A. M., Bouillaud  F., Ricquier  D., Basdevant  A., Guy-Grand  B., Froguel  P.
ISSN
0307-0565
Publication state
Published
Issued date
12/1996
Volume
20
Number
12
Pages
1062-6
Notes
97123603
0307-0565
Journal Article --- Old month value: Dec --- Old uritopublisher value: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8968850
Abstract
OBJECTIVE: Obesity results from an imbalance between caloric intake and energy expenditure, which is partly genetically determined. We have investigated, using a PCR-RFLP assay, the effects on weight gain of two genetic variants of the uncoupling proteins and the beta 3-adrenoceptor, two major expressed proteins of the brown adipose tissue (BAT) involved in thermo-genesis. SUBJECTS: 238 morbidly obese and 91 non obese Caucasian subjects. RESULTS: A high prevalence (27%) in French Caucasians of the A-->G change variation located in the 5' flanking domain of the UCP gene was observed with no significant difference between morbidly obese patients and non obese subjects, suggesting that UCP gene is not a major gene for obesity. However, in the population of morbidly obese subjects, the presence of the A-->G allelic variant of the UCP gene showed to be an associated factor of high weight gain during adult life (odd-ratio: 1.4, P = 0.02). Such an association was previously described for the Trp64Arg mutation of the beta 3-AR gene. Furthermore, an additive effect of these two gene variants on weight gain was observed (Odd-Ratio: 4.95, trend test: P = 0.05). The attributable risks for UCP gene and beta 3-AR gene variants were respectively: 25% and 9%. CONCLUSION: These data support the hypothesis of a possible link between energy balance, BAT and weight gain in human.
Keywords
Adult Alleles Body Temperature Regulation/genetics Brown Fat/metabolism Carrier Proteins/*genetics DNA/analysis Female Genotype Heterozygote Human Male Membrane Proteins/*genetics Middle Age Mitochondria/metabolism Obesity, Morbid/*genetics *Point Mutation Polymerase Chain Reaction Polymorphism (Genetics) Receptors, Adrenergic, beta/*genetics Receptors, Adrenergic, beta-3 Support, Non-U.S. Gov't Weight Gain/*genetics
Pubmed
Web of science
Create date
03/03/2008 16:16
Last modification date
03/03/2018 18:31
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