Cutting edge: thymic NK cells develop independently from T cell precursors.

Details

Serval ID
serval:BIB_792C298D3A0B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cutting edge: thymic NK cells develop independently from T cell precursors.
Journal
Journal of Immunology
Author(s)
Ribeiro V.S., Hasan M., Wilson A., Boucontet L., Pereira P., Lesjean-Pottier S., Satoh-Takayama N., Di Santo J.P., Vosshenrich C.A.
ISSN
1550-6606[electronic], 0022-1767[linking]
Publication state
Published
Issued date
2010
Volume
185
Number
9
Pages
4993-4997
Language
english
Abstract
Although NK cells in the mouse are thought to develop in the bone marrow, a small population of NK cells in the thymus has been shown to derive from a GATA3-dependent pathway. Characteristically, thymic NK cells express CD127 and few Ly49 molecules and lack CD11b. Because these NK cells develop in the thymus, the question of their relationship to the T cell lineage has been raised. Using several different mouse models, we find that unlike T cells, thymic NK cells are not the progeny of Rorc-expressing progenitors and do not express Rag2 or rearrange the TCRγ locus. We further demonstrate that thymic NK cells develop independently of the Notch signaling pathway, supporting the idea that thymic NK cells represent bona fide NK cells that can develop independently of all T cell precursors.
Keywords
Animals, Cell Differentiation/immunology, Cell Lineage/immunology, Cell Separation, Flow Cytometry, Hematopoietic Stem Cells/cytology, Hematopoietic Stem Cells/immunology, Killer Cells, Natural/cytology, Mice, Mice, Inbred C57BL, Mice, Transgenic, Polymerase Chain Reaction, Precursor Cells, T-Lymphoid/cytology, Thymus Gland/cytology
Pubmed
Web of science
Open Access
Yes
Create date
02/02/2011 9:46
Last modification date
20/08/2019 14:35
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