Effects of prolonged administration of the angiotensin converting enzyme inhibitor CGS 16617 in normotensive volunteers.
Details
Serval ID
serval:BIB_78D457293C1C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of prolonged administration of the angiotensin converting enzyme inhibitor CGS 16617 in normotensive volunteers.
Journal
European journal of clinical pharmacology
ISSN
0031-6970
Publication state
Published
Issued date
1989
Peer-reviewed
Oui
Volume
36
Number
6
Pages
587-91
Language
english
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
A new, orally active angiotensin converting enzyme (ACE) inhibitor, CGS 16617, has been evaluated in normotensive subjects during acute and prolonged administration. Single ascending doses of CGS 16617 20 to 100 mg were given to 9 normotensive volunteers at one week intervals and the changes in blood pressure, plasma ACE and renin activity were examined up to 72 h after drug intake. Also, CGS 16617 50 mg/day or placebo were given for 30 days to 8 and 6 normotensive subjects, respectively, maintained on an unrestricted salt diet. Blood pressure was measured daily in the office and ambulatory blood pressure profiles were also obtained before, during and after therapy, using the Remler M 2000 blood pressure recording system. CGS 16617 was an effective and long lasting ACE inhibitor. It did not induce a consistent change in blood pressure, but, the individual responses were very variable and several subjects experienced a clear decrease in the average of the blood pressures recorded during the daytime.
Keywords
Administration, Oral, Adult, Angiotensin-Converting Enzyme Inhibitors, Benzazepines, Blood Pressure, Humans, Male, Peptidyl-Dipeptidase A, Renin, Time Factors
Pubmed
Web of science
Create date
17/11/2008 8:57
Last modification date
20/08/2019 14:35