T1-weighted dynamic contrast-enhanced brain magnetic resonance imaging: A preliminary study with low infusion rate in pediatric patients.

Details

Serval ID
serval:BIB_78C7159C5575
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
T1-weighted dynamic contrast-enhanced brain magnetic resonance imaging: A preliminary study with low infusion rate in pediatric patients.
Journal
The neuroradiology journal
Author(s)
Rochetams B.B., Marechal B., Cottier J.P., Gaillot K., Sembely-Taveau C., Sirinelli D., Morel B.
ISSN
2385-1996 (Electronic)
ISSN-L
1971-4009
Publication state
Published
Issued date
10/2017
Peer-reviewed
Oui
Volume
30
Number
5
Pages
429-436
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Background The aim of this preliminary study is to evaluate the results of T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in pediatric patients at 1.5T, with a low peripheral intravenous gadoteric acid injection rate of 1 ml/s. Materials and methods Children with neurological symptoms were examined prospectively with conventional MRI and T1-weighted DCE MRI. An magnetic resonance perfusion analysis method was used to obtain time-concentration curves (persistent pattern, type-I; plateau pattern, type-II; washout pattern, type-III) and to calculate pharmacokinetic parameters. A total of two radiologists manually defined regions of interest (ROIs) in the part of the lesion exhibiting the greatest contrast enhancement and in the surrounding normal or contralateral tissue. Lesion/surrounding tissue or contralateral tissue pharmacokinetic parameter ratios were calculated. Tumors were categorized by grade (I-IV) using the World Health Organization (WHO) Grade. Mann-Whitney testing and receiver-operating characteristic (ROC) curves were performed. Results A total of nine boys and nine girls (mean age 10.5 years) were included. Lesions consisted of 10 brain tumors, 3 inflammatory lesions, 3 arteriovenous malformations and 2 strokes. We obtained analyzable concentration-time curves for all patients (6 type-I, 9 type-II, 3 type-III). K(trans) between tumor tissue and surrounding or contralateral tissue was significantly different ( p = 0.034). K(trans) ratios were significantly different between grade I tumors and grade IV tumors ( p = 0.027) and a K(trans) ratio value superior to 0.63 appeared to be discriminant to determine a grade IV of malignancy. Conclusions Our results confirm the feasibility of pediatric T1-weighted DCE MRI at 1.5T with a low injection rate, which could be of great value in differentiating brain tumor grades.

Keywords
Dynamic contrast-enhanced MRI, brain, children, pediatric radiology
Pubmed
Create date
06/06/2017 18:10
Last modification date
20/08/2019 14:35
Usage data