Detection and quantification of inbreeding depression for complex traits from SNP data.

Details

Serval ID
serval:BIB_7865A5973F0A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Detection and quantification of inbreeding depression for complex traits from SNP data.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Yengo L., Zhu Z., Wray N.R., Weir B.S., Yang J., Robinson M.R., Visscher P.M.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
08/08/2017
Peer-reviewed
Oui
Volume
114
Number
32
Pages
8602-8607
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Quantifying the effects of inbreeding is critical to characterizing the genetic architecture of complex traits. This study highlights through theory and simulations the strengths and shortcomings of three SNP-based inbreeding measures commonly used to estimate inbreeding depression (ID). We demonstrate that heterogeneity in linkage disequilibrium (LD) between causal variants and SNPs biases ID estimates, and we develop an approach to correct this bias using LD and minor allele frequency stratified inference (LDMS). We quantified ID in 25 traits measured in [Formula: see text] participants of the UK Biobank, using LDMS, and confirmed previously published ID for 4 traits. We find unique evidence of ID for handgrip strength, waist/hip ratio, and visual and auditory acuity (ID between -2.3 and -5.2 phenotypic SDs for complete inbreeding; [Formula: see text]). Our results illustrate that a careful choice of the measure of inbreeding combined with LDMS stratification improves both detection and quantification of ID using SNP data.
Keywords
Consanguinity, Databases, Nucleic Acid, Female, Humans, Linkage Disequilibrium, Male, Models, Genetic, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, directional dominance, homozygosity, inbreeding depression, quantitative genetics, single-nucleotide polymorphism
Pubmed
Web of science
Open Access
Yes
Create date
06/12/2017 12:42
Last modification date
20/08/2019 14:35
Usage data