The rise and fall in menopausal hormone therapy and breast cancer incidence.

Details

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State: Public
Version: author
Serval ID
serval:BIB_785ECDF75D01
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The rise and fall in menopausal hormone therapy and breast cancer incidence.
Journal
The Breast
Author(s)
Pelucchi Claudio, Levi Fabio, La Vecchia Carlo
ISSN
1532-3080[electronic], 0960-9776[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
19
Number
3
Pages
198-201
Language
english
Abstract
Studies conducted in different areas of North America and Europe showed a 5-10% decline in the incidence of breast cancer following reductions up to 70% in menopause hormone therapy (HT) use after 2002. The observation that the decline was larger in (or limited to) women aged > or =50 years weighs in favour of an effect of reduced HT use on breast cancer incidence. However, changes in screening are also likely to play a role in the decreasing incidence of breast cancer observed in several countries. In particular, the technical improvements and the increased effectiveness of breast cancer screening and detection during the 1990s led to a decreased number of pre-clinical cases found by screening in subsequent years. Further, disentangling the effects of HT use and screening is difficult, as women who stop using HT may also undergo mammography screening less frequently. Thus, the reasons of the falls in incidence remain open to discussion.
Keywords
Aged, Breast Neoplasms/epidemiology, Breast Neoplasms/pathology, Estrogen Replacement Therapy, Female, Humans, Incidence, Middle Aged
Pubmed
Web of science
Create date
24/11/2010 9:55
Last modification date
20/08/2019 14:35
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