EBV-associated lymphoproliferative syndrome with a distinct 69 base-pair deletion in the LMP-1 oncogene
Details
Serval ID
serval:BIB_785D2690546B
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
EBV-associated lymphoproliferative syndrome with a distinct 69 base-pair deletion in the LMP-1 oncogene
Journal
British Journal of Haematology
ISSN
0007-1048 (Print)
Publication state
Published
Issued date
12/1995
Volume
91
Number
4
Pages
938-40
Notes
Case Reports
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
We describe an immunocompetent 12-year-old boy with chronic EBV infection and lymphoid interstitial pneumonitis. Lymph node biopsies showed effacement of the architecture with polymorphic cellular infiltrates, consisting predominantly of T cells and natural killer cells. No clonal rearrangement of TCR or immunoglobulin genes was seen. DNA was extracted from hilar lymph nodes; sequencing of the carboxy terminal region of the latent membrane protein 1 (LMP-1) oncogene revealed a 69 base-pair deletion and four point mutations. Immunosuppressive treatment with prednisone and cyclosporine reversed the lymphadenopathy.
Keywords
Base Composition
Base Sequence
Child
Cyclosporine/therapeutic use
DNA Primers/genetics
Electrophoresis, Agar Gel
*Gene Deletion
Herpesviridae Infections/drug therapy/*genetics/pathology
Herpesvirus 4, Human/*immunology
Humans
Lung Diseases, Interstitial/drug therapy/genetics/pathology
Lymph Nodes/pathology
Male
Molecular Sequence Data
Point Mutation
Polymerase Chain Reaction
Prednisolone/therapeutic use
Tumor Virus Infections/drug therapy/*genetics/pathology
Viral Matrix Proteins/*genetics
Pubmed
Web of science
Create date
25/01/2008 15:36
Last modification date
20/08/2019 15:35
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