Cognitive impact of Alzheimer disease neuronal pathology: lessons from centenarians

Details

Serval ID
serval:BIB_78417E53B60E
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Cognitive impact of Alzheimer disease neuronal pathology: lessons from centenarians
Author(s)
Gunten Armin von, Kövari Enikö, Bussière Thierry, Rivara Claire Bénédicte, Gold Gabriel, Bouras Constantin, Hof Patrick R., Giannakopoulos Panteleimon
ISBN
0197-4580
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
27
Series
Neurobiology of Aging
Pages
9
Language
english
Notes
SAPHIRID:61673
Abstract
The relative contribution of Alzheimer disease (AD) hippocampal neuronal pathology in cognitive decline is still matter of debate. To address this issue, we performed a stereologic analysis of layer II of the entorhinal cortex and the CA1 field of the hippocampus in 34 autopsy cases covering the whole spectrum of old age (with 30% of nonagenarians and centenarians) and Clinical Dementia Rating (CDR) scale scores. In both areas, the proportion of NFT-containing neurons increased steadily as a function of the CDR score. Questionable dementia was associated with a 1.9% neuronal loss in the entorhinal cortex and 26% in the CA1 field. NFT numbers predicted only 38% of the neuron number variability in the entorhinal cortex and 55% in the CA1 field. Neuron counts in the entorhinal cortex and both neuron and NFT counts in the CA1 field were significantly associated with cognitive status explaining 25% and 44% of the CDR variability, respectively. Our data reveal a dissociation between the patterns of progression of NFT and neuronal loss in the entorhinal cortex and CA1 field. Moreover, they show that less than 50% of the cognitive variability may be attributable to AD neuronal pathology in these areas.
Create date
10/03/2008 11:04
Last modification date
20/08/2019 14:35
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