Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects

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Serval ID
serval:BIB_77DFB67A1A5E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects
Journal
Intensive Care Medicine
Author(s)
Pluess  T. T., Hayoz  D., Berger  M. M., Tappy  L., Revelly  J. P., Michaeli  B., Carpentier  Y. A., Chiolero  R. L.
ISSN
0342-4642 (Print)
Publication state
Published
Issued date
05/2007
Volume
33
Number
5
Pages
789-97
Notes
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: May
Abstract
OBJECTIVE: To assess the effects of intravenous fish oil fat emulsion on the metabolic alterations induced by lipopolysaccharide (LPS) challenge in healthy volunteers. DESIGN: Two groups of eight healthy subjects were randomized to receive either two pharmacological doses of intravenous FO fat emulsion or no treatment. The FO group received twice 0.5 g/kg 10% emulsion (Omegaven) 48 and 24h before investigation. LPS (2 ng/kg) was injected as a bolus on the investigation day. Systemic parameters, indirect calorimetry, heart rate variability, and platelet membrane phospholipid composition were measured. RESULTS: Basal EPA and DHA content in platelet phospholipids was low (0.28% and 2.54%, respectively) and increased significantly after FO to 1.68% and 3.32%. LPS induced reproducible effects in all subjects. Fever was higher in the control [corrected] group than in FO group [corrected] the difference was significant from t (120) until t (360). FO blunted the neuroendocrine response: the rise in plasma norepinephrine was sevenfold lower at t (120) while the ACTH peak was fourfold lower. Tumor necrosis factor alpha was significantly lower between t (360) and t (180) in the FO group. CONCLUSIONS: Two doses of intravenous FO fat emulsion modified the phospholipid composition of platelets in healthy subjects. FO blunted fever and increased the neuroendocrine and the inflammatory responses to LPS.
Keywords
Adult Baroreflex/*drug effects Endotoxins/*adverse effects/antagonists & inhibitors *Fat Emulsions, Intravenous/pharmacology Fish Oils/administration & dosage/*pharmacology Heart Rate/drug effects Humans Inflammation/blood/prevention & control/*therapy *Lipopolysaccharides Male
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:36
Last modification date
01/10/2019 6:18
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