Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts
Details
Serval ID
serval:BIB_77B16B511776
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts
Journal
Kidney Int
Working group(s)
Chronic Kidney Disease Prognosis Consortium
ISSN
1523-1755 (Electronic))
ISSN-L
0085-2538
Publication state
Published
Issued date
2011
Volume
79
Number
12
Pages
1331-40
Language
english
Notes
Astor, Brad C
Matsushita, Kunihiro
Gansevoort, Ron T
van der Velde, Marije
Woodward, Mark
Levey, Andrew S
Jong, Paul E de
Coresh, Josef
de Jong, Paul E
El-Nahas, Meguid
Eckardt, Kai-Uwe
Kasiske, Bertram L
Wright, Jackson
Appel, Larry
Greene, Tom
Levin, Adeera
Djurdjev, Ognjenka
Wheeler, David C
Landray, Martin J
Townend, John N
Emberson, Jonathan
Clark, Laura E
Macleod, Alison
Marks, Angharad
Ali, Tariq
Fluck, Nicholas
Prescott, Gordon
Smith, David H
Weinstein, Jessica R
Johnson, Eric S
Thorp, Micah L
Wetzels, Jack F
Blankestijn, P J
van Zuilen, A D
Menon, Vandana
Sarnak, Mark
Beck, Gerald
Kronenberg, Florian
Kollerits, Barbara
Froissart, Marc
Stengel, Benedicte
Metzger, Marie
Remuzzi, Giuseppe
Ruggenenti, Piero
Perna, Annalisa
Heerspink, H J Lambers
Brenner, Barry
de Zeeuw, Dick
Rossing, Peter
Parving, Hans-Henrik
Auguste, Priscilla
Veldhuis, Kasper
Wang, Yaping
Camarata, Laura
Thomas, Beverly
Manley, Tom
eng
CZH/4/656/Chief Scientist Office/United Kingdom
K23 DK002904/DK/NIDDK NIH HHS/
K23 DK067303/DK/NIDDK NIH HHS/
U01 DK035073/DK/NIDDK NIH HHS/
Meta-Analysis
Research Support, Non-U.S. Gov't
2011/02/04 06:00
Kidney Int. 2011 Jun;79(12):1331-40. doi: 10.1038/ki.2010.550. Epub 2011 Feb 2.
Matsushita, Kunihiro
Gansevoort, Ron T
van der Velde, Marije
Woodward, Mark
Levey, Andrew S
Jong, Paul E de
Coresh, Josef
de Jong, Paul E
El-Nahas, Meguid
Eckardt, Kai-Uwe
Kasiske, Bertram L
Wright, Jackson
Appel, Larry
Greene, Tom
Levin, Adeera
Djurdjev, Ognjenka
Wheeler, David C
Landray, Martin J
Townend, John N
Emberson, Jonathan
Clark, Laura E
Macleod, Alison
Marks, Angharad
Ali, Tariq
Fluck, Nicholas
Prescott, Gordon
Smith, David H
Weinstein, Jessica R
Johnson, Eric S
Thorp, Micah L
Wetzels, Jack F
Blankestijn, P J
van Zuilen, A D
Menon, Vandana
Sarnak, Mark
Beck, Gerald
Kronenberg, Florian
Kollerits, Barbara
Froissart, Marc
Stengel, Benedicte
Metzger, Marie
Remuzzi, Giuseppe
Ruggenenti, Piero
Perna, Annalisa
Heerspink, H J Lambers
Brenner, Barry
de Zeeuw, Dick
Rossing, Peter
Parving, Hans-Henrik
Auguste, Priscilla
Veldhuis, Kasper
Wang, Yaping
Camarata, Laura
Thomas, Beverly
Manley, Tom
eng
CZH/4/656/Chief Scientist Office/United Kingdom
K23 DK002904/DK/NIDDK NIH HHS/
K23 DK067303/DK/NIDDK NIH HHS/
U01 DK035073/DK/NIDDK NIH HHS/
Meta-Analysis
Research Support, Non-U.S. Gov't
2011/02/04 06:00
Kidney Int. 2011 Jun;79(12):1331-40. doi: 10.1038/ki.2010.550. Epub 2011 Feb 2.
Abstract
We studied here the independent associations of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in individuals with chronic kidney disease (CKD). We performed a collaborative meta-analysis of 13 studies totaling 21,688 patients selected for CKD of diverse etiology. After adjustment for potential confounders and albuminuria, we found that a 15 ml/min per 1.73 m(2) lower eGFR below a threshold of 45 ml/min per 1.73 m(2) was significantly associated with mortality and ESRD (pooled hazard ratios (HRs) of 1.47 and 6.24, respectively). There was significant heterogeneity between studies for both HR estimates. After adjustment for risk factors and eGFR, an eightfold higher albumin- or protein-to-creatinine ratio was significantly associated with mortality (pooled HR 1.40) without evidence of significant heterogeneity and with ESRD (pooled HR 3.04), with significant heterogeneity between HR estimates. Lower eGFR and more severe albuminuria independently predict mortality and ESRD among individuals selected for CKD, with the associations stronger for ESRD than for mortality. Thus, these relationships are consistent with CKD stage classifications based on eGFR and suggest that albuminuria provides additional prognostic information among individuals with CKD.
Keywords
Adult, Aged, Albuminuria/diagnosis/*etiology/*mortality/physiopathology, Biomarkers/blood/urine, Chi-Square Distribution, Cohort Studies, Creatine/blood, Disease Progression, Female, *Glomerular Filtration Rate, Humans, Kidney/*physiopathology, Kidney Diseases/*complications/diagnosis/*mortality/physiopathology, Kidney Failure, Chronic/diagnosis/*etiology/*mortality/physiopathology, Male, Middle Aged, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Regression Analysis, Risk Assessment, Risk Factors
Pubmed
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Open Access
Yes
Create date
03/03/2016 17:49
Last modification date
21/08/2019 6:35