Stairs instead of elevators at the workplace decreases PCSK9 levels in a healthy population.

Details

Serval ID
serval:BIB_77AB1D8A01A4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Stairs instead of elevators at the workplace decreases PCSK9 levels in a healthy population.
Journal
European journal of clinical investigation
Author(s)
Kamani C.H., Gencer B., Montecucco F., Courvoisier D., Vuilleumier N., Meyer P., Mach F.
ISSN
1365-2362 (Electronic)
ISSN-L
0014-2972
Publication state
Published
Issued date
10/2015
Peer-reviewed
Oui
Volume
45
Number
10
Pages
1017-1024
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Regular physical activity is recommended to lower low-density lipoprotein cholesterol (LDL-C) in a healthy population. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) was shown to reduce (LDL-C) levels; however, the impact of physical exercise on PCSK9 levels remains unclear.
We used data from 67 healthy hospital employees who participated in a 6-month intervention promoting active use of stairs instead of elevators during 3 months, followed by 3 months without recommendation. We confirmed the degree of physical activity with estimated aerobic capacity (VO2 max ) and measured serum PCSK9 levels at baseline, 3 and 6 month. Using a multilevel regression model, we analysed changes of PCSK9 levels over time adjusting for age, gender, aerobic capacity, baseline LDL-C, and LDL-C and body mass index (BMI) changes.
At baseline, PCSK9 levels were associated with higher aerobic capacity (P-value = 0·024). At 3 months, we observed a significant decrease in mean PCSK9 levels from 403·6 to 324·3 ng/mL (P-value = 0·001), as well a significant decrease in mean LDL-C levels from 3·5 to 3·3 mM (P-value = 0·01). During this period, mean aerobic capacity (VO2 max ) increased from 37·0 to 40·4 mL/kg/min (P-value < 0·001). Physical activity was independently associated with a decrease in PCSK9 levels after adjustment for age, gender, baseline aerobic capacity, and LDL-C and BMI changes.
Daily physical activity at the work place is independently associated with a decrease in PCSK9 levels over time.
Keywords
Adult, Biomarkers/metabolism, Elevators and Escalators, Exercise/physiology, Female, Healthy Volunteers, Humans, Male, Middle Aged, Proprotein Convertase 9, Proprotein Convertases/metabolism, Serine Endopeptidases/metabolism, Workplace, Biomarkers, PCSK9, lifestyle intervention, lipids, physical exercise
Pubmed
Web of science
Create date
14/03/2024 12:21
Last modification date
14/03/2024 12:22
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