Preoperative inhibition of angiotensin-converting enzyme improves systemic and renal haemodynamic changes during aortic abdominal surgery.

Details

Serval ID
serval:BIB_7756A34E5AD8
Type
Article: article from journal or magazin.
Collection
Publications
Title
Preoperative inhibition of angiotensin-converting enzyme improves systemic and renal haemodynamic changes during aortic abdominal surgery.
Journal
British Journal of Anaesthesia
Author(s)
Licker M., Bednarkiewicz M., Neidhart P., Prêtre R., Montessuit M., Favre H., Morel D.R.
ISSN
0007-0912 (Print)
ISSN-L
0007-0912
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
76
Number
5
Pages
632-639
Language
english
Abstract
We studied 22 patients undergoing aortic surgery, allocated randomly to receive, before induction of anaesthesia, a single i.v. dose of enalapril 50 micrograms kg-1 or saline. During infrarenal aortic cross-clamping, we observed similar reductions in oxygen uptake in the two groups, despite greater systemic oxygen delivery in enalapril-treated patients; angiotensin-converting enzyme inhibition prevented the reduction in cardiac output and attenuated the decrease in glomerular filtration. Changes in glomerular filtration secondary to aortic clamping were related positively to changes in renal plasma flow (r = 0.83 (saline group) and r = 0.65 (enalapril group)). Creatinine clearance on the first day after operation was significantly higher in the enalapril compared with the saline group. We conclude that enalapril pretreatment is effective in improving systemic oxygen delivery, renal plasma flow and glomerular filtration during aortic abdominal surgery.
Pubmed
Web of science
Create date
16/12/2014 18:05
Last modification date
20/08/2019 14:34
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