Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Köttgen, A.; Albrecht, E.; Teumer, A.; Vitart, V.; Krumsiek, J.; Hundertmark, C.; Pistis, G.; Ruggiero, D.; O'Seaghdha, C.M.; Haller, T.; Yang, Q.; Tanaka, T.; Johnson, A.D.; Kutalik, Z.; Smith, A.V.; Shi, J.; Struchalin, M.; Middelberg, R.P.; Brown, M.J.; Gaffo, A.L.; Pirastu, N.; Li, G.; Hayward, C.; Zemunik, T.; Huffman, J.; Yengo, L.; Zhao, J.H.; Demirkan, A.; Feitosa, M.F.; Liu, X.; Malerba, G.; Lopez, L.M.; van der Harst, P.; Li, X.; Kleber, M.E.; Hicks, A.A.; Nolte, I.M.; Johansson, A.; Murgia, F.; Wild, S.H.; Bakker, S.J.; Peden, J.F.; Dehghan, A.; Steri, M.; Tenesa, A.; Lagou, V.; Salo, P.; Mangino, M.; Rose, L.M.; Lehtimäki, T.; Woodward, O.M.; Okada, Y.; Tin, A.; Müller, C.; Oldmeadow, C.; Putku, M.; Czamara, D.; Kraft, P.; Frogheri, L.; Thun, G.A.; Grotevendt, A.; Gislason, G.K.; Harris, T.B.; Launer, L.J.; McArdle, P.; Shuldiner, A.R.; Boerwinkle, E.; Coresh, J.; Schmidt, H.; Schallert, M.; Martin, N.G.; Montgomery, G.W.; Kubo, M.; Nakamura, Y.; Tanaka, T.; Munroe, P.B.; Samani, N.J.; Jacobs, D.R.; Liu, K.; D'Adamo, P.; Ulivi, S.; Rotter, J.I.; Psaty, B.M.; Vollenweider, P.; Waeber, G.; Campbell, S.; Devuyst, O.; Navarro, P.; Kolcic, I.; Hastie, N.; Balkau, B.; Froguel, P.; Esko, T.; Salumets, A.; Khaw, K.T.; Langenberg, C.; Wareham, N.J.; Isaacs, A.; Kraja, A.; Zhang, Q.; Wild, P.S.; Scott, R.J.; Holliday, E.G.; Org, E.; Viigimaa, M.; Bandinelli, S.; Metter, J.E.; Lupo, A.; Trabetti, E.; Sorice, R.; Döring, A.; Lattka, E.; Strauch, K.; Theis, F.; Waldenberger, M.; Wichmann, H.E.; Davies, G.; Gow, A.J.; Bruinenberg, M.; Stolk, R.P.; Stolk, R.P.; Kooner, J.S.; Zhang, W.; Winkelmann, B.R.; Boehm, B.O.; Lucae, S.; Penninx, B.W.; Smit, J.H.; Curhan, G.; Mudgal, P.; Plenge, R.M.; Portas, L.; Persico, I.; Kirin, M.; Wilson, J.F.; Mateo Leach, I.; van Gilst, W.H.; Goel, A.; Ongen, H.; Hofman, A.; Rivadeneira, F.; Uitterlinden, A.G.; Imboden, M.; von Eckardstein, A.; Cucca, F.; Nagaraja, R.; Piras, M.G.; Nauck, M.; Schurmann, C.; Budde, K.; Ernst, F.; Farrington, S.M.; Theodoratou, E.; Prokopenko, I.; Stumvoll, M.; Jula, A.; Perola, M.; Salomaa, V.; Shin, S.Y.; Spector, T.D.; Sala, C.; Ridker, P.M.; Kähönen, M.; Viikari, J.; Hengstenberg, C.; Nelson, C.P.; Meschia, J.F.; Meschia, J.F.; Nalls, M.A.; Sharma, P.; Singleton, A.B.; Kamatani, N.; Zeller, T.; Burnier, M.; Attia, J.; Laan, M.; Klopp, N.; Hillege, H.L.; Kloiber, S.; Choi, H.; Pirastu, M.; Tore, S.; Probst-Hensch, N.M.; Völzke, H.; Gudnason, V.; Parsa, A.; Schmidt, R.; Whitfield, J.B.; Fornage, M.; Gasparini, P.; Siscovick, D.S.; Pola?ek O.,; Campbell, H.; Rudan, I.; Bouatia-Naji, N.; Metspalu, A.; Loos, R.J.; van Duijn, C.M.; Borecki, I.B.; Ferrucci, L.; Gambaro, G.; Deary, I.J.; Wolffenbuttel, B.H.; Chambers, J.C.; März, W.; Pramstaller, P.P.; Snieder, H.; Gyllensten, U.; Wright, A.F.; Navis, G.; Watkins, H.; Witteman, J.C.; Sanna, S.; Schipf, S.; Dunlop, M.G.; Tönjes, A.; Ripatti, S.; Soranzo, N.; Toniolo, D.; Chasman, D.I.; Raitakari, O.; Kao, W.H.; Ciullo, M.; Fox, C.S.; Caulfield, M.; Bochud, M.; Gieger, C.

doi:10.1038/ng.2500

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Details

Download: BIB_772703318942.P001.pdf (1621.04 [Ko])
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Version: author

Serval ID

serval:BIB_772703318942

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Journal

Nature Genetics

Author(s)

Köttgen A., Albrecht E., Teumer A., Vitart V., Krumsiek J., Hundertmark C., Pistis G., Ruggiero D., O'Seaghdha C.M., Haller T., Yang Q., Tanaka T., Johnson A.D., Kutalik Z., Smith A.V., Shi J., Struchalin M., Middelberg R.P., Brown M.J., Gaffo A.L., Pirastu N., Li G., Hayward C., Zemunik T., Huffman J., Yengo L., Zhao J.H., Demirkan A., Feitosa M.F., Liu X., Malerba G., Lopez L.M., van der Harst P., Li X., Kleber M.E., Hicks A.A., Nolte I.M., Johansson A., Murgia F., Wild S.H., Bakker S.J., Peden J.F., Dehghan A., Steri M., Tenesa A., Lagou V., Salo P., Mangino M., Rose L.M., Lehtimäki T., Woodward O.M., Okada Y., Tin A., Müller C., Oldmeadow C., Putku M., Czamara D., Kraft P., Frogheri L., Thun G.A., Grotevendt A., Gislason G.K., Harris T.B., Launer L.J., McArdle P., Shuldiner A.R., Boerwinkle E., Coresh J., Schmidt H., Schallert M., Martin N.G., Montgomery G.W., Kubo M., Nakamura Y., Tanaka T., Munroe P.B., Samani N.J., Jacobs D.R., Liu K., D'Adamo P., Ulivi S., Rotter J.I., Psaty B.M., Vollenweider P., Waeber G., Campbell S., Devuyst O., Navarro P., Kolcic I., Hastie N., Balkau B., Froguel P., Esko T., Salumets A., Khaw K.T., Langenberg C., Wareham N.J., Isaacs A., Kraja A., Zhang Q., Wild P.S., Scott R.J., Holliday E.G., Org E., Viigimaa M., Bandinelli S., Metter J.E., Lupo A., Trabetti E., Sorice R., Döring A., Lattka E., Strauch K., Theis F., Waldenberger M., Wichmann H.E., Davies G., Gow A.J., Bruinenberg M., Stolk R.P., Stolk R.P., Kooner J.S., Zhang W., Winkelmann B.R., Boehm B.O., Lucae S., Penninx B.W., Smit J.H., Curhan G., Mudgal P., Plenge R.M., Portas L., Persico I., Kirin M., Wilson J.F., Mateo Leach I., van Gilst W.H., Goel A., Ongen H., Hofman A., Rivadeneira F., Uitterlinden A.G., Imboden M., von Eckardstein A., Cucca F., Nagaraja R., Piras M.G., Nauck M., Schurmann C., Budde K., Ernst F., Farrington S.M., Theodoratou E., Prokopenko I., Stumvoll M., Jula A., Perola M., Salomaa V., Shin S.Y., Spector T.D., Sala C., Ridker P.M., Kähönen M., Viikari J., Hengstenberg C., Nelson C.P., Meschia J.F., Meschia J.F., Nalls M.A., Sharma P., Singleton A.B., Kamatani N., Zeller T., Burnier M., Attia J., Laan M., Klopp N., Hillege H.L., Kloiber S., Choi H., Pirastu M., Tore S., Probst-Hensch N.M., Völzke H., Gudnason V., Parsa A., Schmidt R., Whitfield J.B., Fornage M., Gasparini P., Siscovick D.S., Pola?ek O. , Campbell H., Rudan I., Bouatia-Naji N., Metspalu A., Loos R.J., van Duijn C.M., Borecki I.B., Ferrucci L., Gambaro G., Deary I.J., Wolffenbuttel B.H., Chambers J.C., März W., Pramstaller P.P., Snieder H., Gyllensten U., Wright A.F., Navis G., Watkins H., Witteman J.C., Sanna S., Schipf S., Dunlop M.G., Tönjes A., Ripatti S., Soranzo N., Toniolo D., Chasman D.I., Raitakari O., Kao W.H., Ciullo M., Fox C.S., Caulfield M., Bochud M., Gieger C.

Working group(s)

LifeLines Cohort Study, CARDIoGRAM Consortium, DIAGRAM Consortium, ICBP Consortium, MAGIC Consortium

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

2013

Peer-reviewed

Oui

Volume

Number

Pages

145-154

Language

english

Notes

Publication types: Journal Article Publication Status: ppublish PDF type: Article

Abstract

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

URN

urn:nbn:ch:serval-BIB_7727033189428

OAI-PMH

oai:serval.unil.ch:BIB_772703318942

DOI

10.1038/ng.2500

Pubmed

23263486

Web of science

000314333000009

Open Access

Yes