Limits to anatomical accuracy of diffusion tractography using modern approaches.

Details

Serval ID
serval:BIB_7721654B33E0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Limits to anatomical accuracy of diffusion tractography using modern approaches.
Journal
NeuroImage
Author(s)
Schilling K.G., Nath V., Hansen C., Parvathaneni P., Blaber J., Gao Y., Neher P., Aydogan D.B., Shi Y., Ocampo-Pineda M., Schiavi S., Daducci A., Girard G., Barakovic M., Rafael-Patino J., Romascano D., Rensonnet G., Pizzolato M., Bates A., Fischi E., Thiran J.P., Canales-Rodríguez E.J., Huang C., Zhu H., Zhong L., Cabeen R., Toga A.W., Rheault F., Theaud G., Houde J.C., Sidhu J., Chamberland M., Westin C.F., Dyrby T.B., Verma R., Rathi Y., Irfanoglu M.O., Thomas C., Pierpaoli C., Descoteaux M., Anderson A.W., Landman B.A.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Publication state
Published
Issued date
15/01/2019
Peer-reviewed
Oui
Volume
185
Pages
1-11
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the brain, with a range of applications in both clinical and basic neuroscience. Despite widespread use, tractography has well-known pitfalls that limits the anatomical accuracy of this technique. Numerous modern methods have been developed to address these shortcomings through advances in acquisition, modeling, and computation. To test whether these advances improve tractography accuracy, we organized the 3-D Validation of Tractography with Experimental MRI (3D-VoTEM) challenge at the ISBI 2018 conference. We made available three unique independent tractography validation datasets - a physical phantom and two ex vivo brain specimens - resulting in 176 distinct submissions from 9 research groups. By comparing results over a wide range of fiber complexities and algorithmic strategies, this challenge provides a more comprehensive assessment of tractography's inherent limitations than has been reported previously. The central results were consistent across all sub-challenges in that, despite advances in tractography methods, the anatomical accuracy of tractography has not dramatically improved in recent years. Taken together, our results independently confirm findings from decades of tractography validation studies, demonstrate inherent limitations in reconstructing white matter pathways using diffusion MRI data alone, and highlight the need for alternative or combinatorial strategies to accurately map the fiber pathways of the brain.
Keywords
Connectivity, Diffusion MRI, Phantom, Tracer, Tractography, Validation, White matter
Pubmed
Web of science
Create date
29/10/2018 13:40
Last modification date
18/12/2018 7:11
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