Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?

Details

Serval ID
serval:BIB_76A54C55A3F3
Type
Article: article from journal or magazin.
Collection
Publications
Title
Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?
Journal
Brain
Author(s)
Williams A., Piaton G., Aigrot M.S., Belhadi A., Théaudin M., Petermann F., Thomas J.L., Zalc B., Lubetzki C.
ISSN
1460-2156 (Electronic)
ISSN-L
0006-8950
Publication state
Published
Issued date
10/2007
Peer-reviewed
Oui
Volume
130
Number
Pt 10
Pages
2554-2565
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The presence of demyelinated plaques in the central nervous system is the hallmark of multiple sclerosis (MS). Some plaques remyelinate but others do not, leaving permanent damage. The reasons for this failure of repair are many, but one possible reason is the lack of migration of oligodendrocyte precursor cells to the lesion. The guidance molecules Semaphorin 3A and 3F, already known to direct oligodendroglial migration in development, may also be active in controlling oligodendrocyte precursor cell migration in MS, and hence may determine the ability of plaques to remyelinate. Here, in MS tissue and an experimental model of demyelination, we demonstrate a local source of these molecules around active demyelinating lesions, but not chronic plaques. We also provide evidence for their up-regulation at a distance from the lesion, in the neuronal cell bodies corresponding to the demyelinated axons. We propose that both of these mechanisms influence remyelination.

Keywords
Adult, Aged, Aged, 80 and over, Animals, Apoptosis, Cerebral Cortex/metabolism, Disease Models, Animal, Female, Humans, Intracellular Signaling Peptides and Proteins/genetics, Male, Membrane Proteins/genetics, Membrane Proteins/physiology, Middle Aged, Motor Cortex/metabolism, Multiple Sclerosis/metabolism, Multiple Sclerosis/pathology, Multiple Sclerosis/physiopathology, Myelin Sheath/metabolism, Myelin Sheath/physiology, Nerve Regeneration, Nerve Tissue Proteins/biosynthesis, Nerve Tissue Proteins/genetics, Nerve Tissue Proteins/physiology, Neuroglia/metabolism, Neurons/metabolism, Neurons/pathology, RNA, Messenger/genetics, Rats, Rats, Wistar, Semaphorin-3A/biosynthesis, Semaphorin-3A/genetics, Semaphorin-3A/physiology, Signal Transduction, Up-Regulation
Pubmed
Web of science
Open Access
Yes
Create date
12/12/2017 18:38
Last modification date
20/08/2019 15:33
Usage data