Interferon-alpha therapy in liver transplant recipients: lack of association with increased production of anti-HLA antibodies
Details
Serval ID
serval:BIB_7699F180FCED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Interferon-alpha therapy in liver transplant recipients: lack of association with increased production of anti-HLA antibodies
Journal
American Journal of Transplantation
ISSN
1600-6135
Publication state
Published
Issued date
08/2004
Peer-reviewed
Oui
Volume
4
Number
8
Pages
1352-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug
Research Support, Non-U.S. Gov't --- Old month value: Aug
Abstract
Interferon-alpha (IFN) is a useful treatment for active HCV infection. In kidney transplantation, IFN has been shown to trigger acute rejection with de novo anti-HLA antibodies. Interferon-alpha has not been reported to enhance the risk of acute rejection in HCV-positive liver transplant recipients (LTRs). Sera were collected from 44 LTRs greater than 6 months post-transplant. Sera were tested with ELISA for the presence and the specificity of anti-HLA antibodies. The prevalence of anti-HLA antibodies was 11% and was not significantly different in 13 HCV-positive recipients who received IFN, compared with 10 who did not receive IFN (8% vs. 20%), or with 21 HCV-negative recipients (10%). None of the patients had an acute rejection after starting IFN. In this study, LTRs receiving IFN did not have an increased frequency of anti-HLA antibodies. This may partially explain the safety of IFN previously reported in LTRs requiring antiviral therapy.
Keywords
*Antibodies
Biopsy
Enzyme-Linked Immunosorbent Assay
Female
Graft Rejection
HLA Antigens/*immunology
Hepacivirus/metabolism
Humans
Interferon-alpha/*therapeutic use
Interferons/metabolism
Liver Transplantation/*methods
Male
Reverse Transcriptase Polymerase Chain Reaction
Time Factors
Transplantation, Homologous
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 13:53
Last modification date
20/08/2019 14:33