68Ga-NODAGA-RGDyK PET/CT Imaging in Esophageal Cancer: First-in-Human Imaging.

Details

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State: Serval
Version: Author's accepted manuscript
Serval ID
serval:BIB_768A65543E8F
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
68Ga-NODAGA-RGDyK PET/CT Imaging in Esophageal Cancer: First-in-Human Imaging.
Journal
Clinical nuclear medicine
Author(s)
Van Der Gucht A., Pomoni A., Jreige M., Allemann P., Prior J.O.
ISSN
1536-0229 (Electronic)
ISSN-L
0363-9762
Publication state
Published
Issued date
11/2016
Peer-reviewed
Oui
Volume
41
Number
11
Pages
e491-e492
Language
english
Notes
Publication types: ARTICLE
Publication Status: ppublish
Publication types: JOURNAL ARTICLE
Publication types: Case Reports ; Journal Article

Abstract
Ga-NODAGA-RGDyK(cyclic) and FDG PET/CT were performed in a 39-year-old man for the work-up of a moderately differentiated carcinoma of the gastro-esophageal junction within a clinical study protocol. Although FDG PET images showed intense, diffuse hypermetabolic lesion activity, NODAGA-RGDyK illustrated the neo-angiogenesis process with tracer uptake clearly localized in non-FDG-avid perilesional structures. Neo-angiogenesis is characterized by ανβ3 integrin expression at the lesion surface of newly formed vessels. This case supports evidence that angiogenesis imaging might therefore be a crucial step in early disease identification and localization, metastatization potential, and in monitoring the efficacy of antiangiogenic therapies.

Keywords
Adult, Carcinoma/blood supply, Carcinoma/diagnostic imaging, Coordination Complexes, Esophageal Neoplasms/blood supply, Esophageal Neoplasms/diagnostic imaging, Esophagogastric Junction/blood supply, Esophagogastric Junction/diagnostic imaging, Fluorodeoxyglucose F18, Humans, Male, Neovascularization, Pathologic/diagnostic imaging, Peptides, Cyclic, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals
Pubmed
Create date
23/09/2016 20:03
Last modification date
27/04/2018 7:08
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