In Vivo Targeting of CXCR4-New Horizons.

Details

Serval ID
serval:BIB_768384A9D6F8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
In Vivo Targeting of CXCR4-New Horizons.
Journal
Cancers
Author(s)
Schottelius M., Herrmann K., Lapa C.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
25/11/2021
Peer-reviewed
Oui
Volume
13
Number
23
Pages
5920
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Given its pre-eminent role in the context of tumor cell growth as well as metastasis, the C-X-C motif chemokine receptor 4 (CXCR4) has attracted a lot of interest in the field of nuclear oncology, and clinical evidence on the high potential of CXCR4-targeted theranostics is constantly accumulating. Additionally, since CXCR4 also represents a key player in the orchestration of inflammatory responses to inflammatory stimuli, based on its expression on a variety of pro- and anti-inflammatory immune cells (e.g., macrophages and T-cells), CXCR4-targeted inflammation imaging has recently gained considerable attention. Therefore, after briefly summarizing the current clinical status quo of CXCR4-targeted theranostics in cancer, this review primarily focuses on imaging of a broad spectrum of inflammatory diseases via the quantification of tissue infiltration with CXCR4-expressing immune cells. An up-to-date overview of the ongoing preclinical and clinical efforts to visualize inflammation and its resolution over time is provided, and the predictive value of the CXCR4-associated imaging signal for disease outcome is discussed. Since the sensitivity and specificity of CXCR4-targeted immune cell imaging greatly relies on the availability of suitable, tailored imaging probes, recent developments in the field of CXCR4-targeted imaging agents for various applications are also addressed.
Keywords
CXCR4, PET, SPECT, cancer, inflammation, molecular imaging, radioligand therapy
Pubmed
Web of science
Open Access
Yes
Create date
20/12/2021 14:43
Last modification date
05/04/2022 6:36
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