Effect of curative versus palliative surgical treatment for stage III pancreatic cancer patients.

Details

Serval ID
serval:BIB_766A13733D6F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of curative versus palliative surgical treatment for stage III pancreatic cancer patients.
Journal
Journal of the Royal College of Surgeons of Edinburgh
Author(s)
Kymionis G.D., Konstadoulakis M.M., Leandros E., Manouras A., Apostolou A., Alexiou D., Katsaragakis S., Androulakis G.
ISSN
0035-8835 (Print)
ISSN-L
0035-8835
Publication state
Published
Issued date
08/1999
Peer-reviewed
Oui
Volume
44
Number
4
Pages
231-235
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
During the last decade, significant progress has been made in pancreaticoduodenectomy for patients with pancreatic carcinoma. Pancreatic resection performed by surgeons in tertiary referral centres is therefore justified, while the indications for pancreatic resection could be extended in patients with advance stages of disease. The aim of our study is to compare the effect of curative (pancreaticoduodenectomy) versus palliative surgery in patients with stage III pancreatic cancer, during a 20-years period. We retrospectively reviewed the charts of 58 consecutive patients with stage III ductal adenocarcinoma of the head of the pancreas. 23 patients underwent pancreatoduodenectomy with curative intent while the remaining 35 patients had surgery for palliative purposes (combined biliary and gastric bypass was performed in 83%). The hospital mortality rate was similar in both groups (4% vs 6%). 43% of patients undergoing pancreaticoduodenectomy had an uncomplicated post-operative course compared with 49% of patients undergoing palliative bypass. The length of surgical procedure and post-operative hospital stay in pancreaticoduodenectomy group were significant longer compared to those patients undergoing palliative bypass (p = 0.03 and p = 0.02 respectively). The overall actuarial survival was significantly (p < 0.01) longer in the group of patients who underwent pancreaticoduodenectomy compared with the group with palliative intent surgery.
Pancreaticoduodenectomy with curative intent for stage III pancreatic cancer patients, could improve prognosis with similar peri-operative morbidity and mortality when compared with palliative bypass.
Keywords
Adenocarcinoma/mortality, Adenocarcinoma/pathology, Adenocarcinoma/surgery, Adult, Aged, Female, Humans, Length of Stay, Male, Middle Aged, Neoplasm Staging, Palliative Care, Pancreatic Neoplasms/mortality, Pancreatic Neoplasms/pathology, Pancreatic Neoplasms/surgery, Pancreaticoduodenectomy, Prognosis, Retrospective Studies, Survival Analysis
Pubmed
Web of science
Create date
02/10/2019 10:26
Last modification date
06/10/2019 6:26
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