Subretinal mononuclear phagocytes induce cone segment loss via IL-1β.

Details

Serval ID
serval:BIB_75EFEC75DA5C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Subretinal mononuclear phagocytes induce cone segment loss via IL-1β.
Journal
eLife
Author(s)
Eandi C.M., Charles Messance H., Augustin S., Dominguez E., Lavalette S., Forster V., Hu S.J., Siquieros L., Craft C.M., Sahel J.A., Tadayoni R., Paques M., Guillonneau X., Sennlaub F.
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
20/07/2016
Peer-reviewed
Oui
Volume
5
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: epublish
Abstract
Photo-transduction in cone segments (CS) is crucial for high acuity daytime vision. For ill-defined reasons, CS degenerate in retinitis pigmentosa (RP) and in the transitional zone (TZ) of atrophic zones (AZ), which characterize geographic atrophy (GA). Our experiments confirm the loss of cone segments (CS) in the TZ of patients with GA and show their association with subretinal CD14(+)mononuclear phagocyte (MP) infiltration that is also reported in RP. Using human and mouse MPs in vitro and inflammation-prone Cx3cr1(GFP/GFP) mice in vivo, we demonstrate that MP-derived IL-1β leads to severe CS degeneration. Our results strongly suggest that subretinal MP accumulation participates in the observed pathological photoreceptor changes in these diseases. Inhibiting subretinal MP accumulation or Il-1β might protect the CS and help preserve high acuity daytime vision in conditions characterized by subretinal inflammation, such as AMD and RP.
Keywords
Animals, Geographic Atrophy/pathology, Geographic Atrophy/physiopathology, Humans, Interleukin-1beta/metabolism, Mice, Phagocytes/immunology, Retina/pathology, Retinal Cone Photoreceptor Cells/physiology, age-related macular degeneration, human, human biology, interleukin, macrophages, medicine, mouse, neuroscience, outer segments, retinitis pigmentosa, subretinal space
Pubmed
Web of science
Open Access
Yes
Create date
12/03/2021 19:15
Last modification date
26/03/2021 7:35
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