Time course of aquaporin expression after transient focal cerebral ischemia in mice

Details

Serval ID
serval:BIB_75D2F24B3547
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Time course of aquaporin expression after transient focal cerebral ischemia in mice
Journal
Journal of Neuroscience Research
Author(s)
Ribeiro Mde  C., Hirt  L., Bogousslavsky  J., Regli  L., Badaut  J.
ISSN
0360-4012 (Print)
Publication state
Published
Issued date
05/2006
Peer-reviewed
Oui
Volume
83
Number
7
Pages
1231-40
Notes
Comparative Study Journal Article Research Support, Non-U.S. Gov't --- Old month value: May 15
Abstract
Cerebral edema contributes to morbidity and mortality in stroke. Aquaporins (AQPs)-1, -4, and -9 have been identified as the three main water channels in the brain. To clarify their role in water movement, we have compared their expression patterns with brain swelling after transient focal brain ischemia. There were two peaks of maximal hemispheric swelling at 1 hr and at 48 hr after ischemia, coinciding with two peaks of AQP4 expression. At 1 hr after occlusion, AQP4 expression was significantly increased on astrocyte endfeet in the core and in the border of the lesion. At 48 hr, AQP4 expression was increased in astrocytes in the border of the lesion over the whole cell. AQP9 showed a significant induction at 24 hr that increased gradually with time, without correlation with the swelling. The expression of AQP1 remained unchanged. These results suggest that AQP4, but not AQP1 or AQP9, may play an important role in water movement associated with the pathophysiology of edema after transient cerebral ischemia in the mouse.
Keywords
Animals Aquaporin 4/metabolism Aquaporins/*metabolism Astrocytes/*metabolism Blood-Brain Barrier/*metabolism/physiopathology Brain Edema/etiology/*metabolism/physiopathology Cerebral Cortex/*metabolism/physiopathology Cerebral Infarction/complications/metabolism/physiopathology Disease Models, Animal Ischemic Attack, Transient/complications/*metabolism/physiopathology Male Mice Mice, Inbred ICR Microtubule-Associated Proteins/metabolism Time Factors Up-Regulation/physiology
Pubmed
Web of science
Create date
25/01/2008 12:40
Last modification date
20/08/2019 14:33
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