Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study)

Details

Serval ID
serval:BIB_75A876A5DF60
Type
Article: article from journal or magazin.
Collection
Publications
Title
Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study)
Journal
Scandinavian Journal of Work, Environment & Health
Author(s)
Guth Margot, Lefevre Marie, Pilorget Corinne, Coste Astrid, Ahmadi Shukrullah, Danjou Aurélie, Dananché Brigitte, Praud Delphine, Koscinski Isabelle, Papaxanthos Aline, Blagosklonov Oxana, Fauque Patricia, Pérol Olivia, Schüz Joachim, Bujan Louis, Olsson Ann, Fervers Béatrice, Charbotel Barbara
Working group(s)
The TESTIS study group
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Language
english
Abstract
OBJECTIVES: The etiology of testicular germ cell tumors (TGCT) is suspected to be related to prenatal environmental risk factors. Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. The aim of this study was to examine the association between parental occupational exposure to solvents and TGCT risk among their offspring. METHODS: A French nationwide case–control study, TESTIS included 454 TGCT cases and 670 controls frequency-matched on region and 5-year age strata. Participants were interviewed via telephone and provided information on parental occupations at birth. Job-exposure matrices (JEM) developed in the French Matgéné program were used to assign exposure to five petroleum-based solvents, five solvents or groups of oxygenated solvents, and five chlorinated solvents. Odds ratios (OR) for TGCT and 95% confidence intervals (CI) were estimated using conditional logistic regression, adjusting for TGCT risk factors. RESULTS: Occupational exposure to at least one solvent during the year of their son’s birth was 41% among fathers and 21% among mothers. Paternal exposure to at least one solvent showed OR 0.89 (95% CI 0.68–1.15). Exposure to perchloroethylene (OR 1.41, 95% CI 0.55–3.61), methylene chloride (OR 1.13, 95% CI 0.54–2.34) and diesel/kerosene/fuel oil (OR 1.17, 95% CI 0.80–1.73) disclosed OR >1 but with low precision. Our results suggest a possible modest increase in non-seminoma risk for sons whose fathers were highly exposed to trichloroethylene (OR 1.44, 95% CI 0.79–2.63). Maternal exposure to at least one solvent showed OR 0.90 (95% CI 0.65–1.24). When stratifying by birth year, men born in the 1970s experienced an increased TGCT risk following maternal exposure to fuels and petroleum-based solvents (OR 2.74, 95% CI 1.11–6.76). CONCLUSION: Overall, no solid association was found between parental occupational exposure to solvents and TGCT risk. The association found with maternal occupational exposure to fuels and petroleum ...
Keywords
cancer, epidemiology, JEM, job-exposure matrix, organic solvent, prenatal exposure, testicular cancer
Create date
26/09/2024 10:11
Last modification date
27/09/2024 16:46
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