Successful prophylaxis of experimental streptococcal endocarditis with single-dose amoxicillin administered after bacterial challenge

Details

Serval ID
serval:BIB_7560A8DA6CBA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Successful prophylaxis of experimental streptococcal endocarditis with single-dose amoxicillin administered after bacterial challenge
Journal
Journal of Infectious Diseases
Author(s)
Berney  P., Francioli  P.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
02/1990
Volume
161
Number
2
Pages
281-5
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
Rats with catheter-induced aortic vegetations were challenged intravenously with various inoculum sizes of tolerant Streptococcus sanguis or Streptococcus faecalis. Single-dose amoxicillin (40 mg/kg) was given intravenously either 30 min before or 30-240 min after bacterial challenge. Prophylaxis of endocarditis against both strains was successful when the inocula used for challenge were in the range of the minimum inoculum producing bacterial endocarditis in 90% of control animals (ID90) but was less effective or failed with larger inocula or when amoxicillin administration was delayed up to 240 min after bacterial challenge with S. sanguis. In a group of rats profoundly depleted of neutrophils by a rabbit anti-rat neutrophil serum given 30 min after challenge with S. faecalis at ID90, single-dose amoxicillin administered simultaneously with the antiserum was protective, indicating that neutrophils were not required for successful endocarditis prophylaxis.
Keywords
Amoxicillin/pharmacology/*therapeutic use Animals Endocarditis, Bacterial/complications/*prevention & control Enterococcus faecalis/drug effects Female Leukocyte Count Neutropenia/complications Neutrophils/immunology Rats Rats, Inbred Strains Serum Bactericidal Test Streptococcal Infections/complications/*prevention & control Streptococcus sanguis/drug effects
Pubmed
Web of science
Create date
25/01/2008 17:07
Last modification date
20/08/2019 14:32
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