Robot-induced hallucinations in Parkinson's disease depend on altered sensorimotor processing in fronto-temporal network.

Details

Serval ID
serval:BIB_755ED6945C9E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Robot-induced hallucinations in Parkinson's disease depend on altered sensorimotor processing in fronto-temporal network.
Journal
Science translational medicine
Author(s)
Bernasconi F., Blondiaux E., Potheegadoo J., Stripeikyte G., Pagonabarraga J., Bejr-Kasem H., Bassolino M., Akselrod M., Martinez-Horta S., Sampedro F., Hara M., Horvath J., Franza M., Konik S., Bereau M., Ghika J.A., Burkhard P.R., Van De Ville D., Faivre N., Rognini G., Krack P., Kulisevsky J., Blanke O.
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Publication state
Published
Issued date
28/04/2021
Peer-reviewed
Oui
Volume
13
Number
591
Pages
eabc8362
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Hallucinations in Parkinson's disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the induction of presence hallucinations (PHs) and the characterization of a subgroup of patients with PD with enhanced sensitivity for conflicting sensorimotor stimulation and robot-induced PH. We next identify the fronto-temporal network of PH by combining MR-compatible robotics (and sensorimotor stimulation in healthy participants) and lesion network mapping (neurological patients without PD). This PH-network was selectively disrupted in an additional and independent cohort of patients with PD, predicted the presence of symptomatic PH, and associated with cognitive decline. These robotics-neuroimaging findings extend existing sensorimotor hallucination models to PD and reveal the pathological cortical sensorimotor processes of PH in PD, potentially indicating a more severe form of PD that has been associated with psychosis and cognitive decline.
Keywords
Hallucinations, Humans, Neuroimaging, Parkinson Disease, Psychotic Disorders, Robotics
Pubmed
Web of science
Create date
21/05/2021 17:48
Last modification date
30/12/2023 8:08
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