Robot-induced hallucinations in Parkinson's disease depend on altered sensorimotor processing in fronto-temporal network.
Details
Serval ID
serval:BIB_755ED6945C9E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Robot-induced hallucinations in Parkinson's disease depend on altered sensorimotor processing in fronto-temporal network.
Journal
Science translational medicine
ISSN
1946-6242 (Electronic)
ISSN-L
1946-6234
Publication state
Published
Issued date
28/04/2021
Peer-reviewed
Oui
Volume
13
Number
591
Pages
eabc8362
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Hallucinations in Parkinson's disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the induction of presence hallucinations (PHs) and the characterization of a subgroup of patients with PD with enhanced sensitivity for conflicting sensorimotor stimulation and robot-induced PH. We next identify the fronto-temporal network of PH by combining MR-compatible robotics (and sensorimotor stimulation in healthy participants) and lesion network mapping (neurological patients without PD). This PH-network was selectively disrupted in an additional and independent cohort of patients with PD, predicted the presence of symptomatic PH, and associated with cognitive decline. These robotics-neuroimaging findings extend existing sensorimotor hallucination models to PD and reveal the pathological cortical sensorimotor processes of PH in PD, potentially indicating a more severe form of PD that has been associated with psychosis and cognitive decline.
Keywords
Hallucinations, Humans, Neuroimaging, Parkinson Disease, Psychotic Disorders, Robotics
Pubmed
Web of science
Create date
21/05/2021 17:48
Last modification date
30/12/2023 8:08