Physiological and pathophysiological role of the epithelial sodium channel in the control of blood pressure
Details
Serval ID
serval:BIB_755CFCBACF4E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Physiological and pathophysiological role of the epithelial sodium channel in the control of blood pressure
Journal
Kidney and Blood Pressure Research
ISSN
1420-4096
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
19
Number
3-4
Pages
160-65
Notes
Journal Article Research Support, Non-U.S. Gov't Review
Abstract
Blood pressure regulation is an integrated physiological phenomenon known to be influenced by many biological processes and by a variety of environmental factors. Epidemiological studies nevertheless suggest that up to 30% of the variation in blood pressure could be due to genetic factors. Thus, mutations in genes that control blood pressure may be the underlying cause of essential hypertension. Arterial blood pressure is critically dependent on the sodium balance and the regulation of renal sodium excretion is one of the most important homeostatic functions of the body. The identification of genes encoding proteins that transport Na+ across cells of the kidney tubules and of those regulating the activity of these sodium-transporting proteins will therefore bring further insights into the pathophysiology of salt-sensitive hypertension.
Keywords
Animals Blood Pressure/*physiology Carrier Proteins/genetics/metabolism Epithelium/physiology/physiopathology Humans Hypertension/etiology/*physiopathology Ion Transport Kidney Tubules/*physiology/physiopathology Point Mutation Sodium Channels/genetics/*physiology
Pubmed
Web of science
Create date
24/01/2008 14:00
Last modification date
20/08/2019 15:32