Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis

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Serval ID
serval:BIB_7540CFBF4523
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis
Journal
Biochemical and Biophysical Research Communications
Author(s)
Rajesh M., Mukhopadhyay P., Batkai S., Godlewski G., Hasko G., Liaudet L., Pacher P.
ISSN
0006-291X (Print)
Publication state
Published
Issued date
11/2006
Peer-reviewed
Oui
Volume
350
Number
2
Pages
352-7
Language
english
Notes
Journal Article
Research Support, N.I.H., Intramural --- Old month value: Nov 17
Abstract
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which plays an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP are being considered as treatment for cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation, and were also reported to be protective against untoward effects exerted by certain anticancer drugs. Here we show that pharmacological inhibition of PARP with 3-aminobenzamide or PJ-34 dose-dependently reduces VEGF-induced proliferation, migration, and tube formation of human umbilical vein endothelial cells in vitro. These results suggest that treatment with PARP inhibitors may exert additional benefits in various cancers and retinopathies by decreasing angiogenesis.
Keywords
Angiogenesis Inhibitors/*pharmacology Benzamides/pharmacology Cell Movement/drug effects Cell Proliferation/drug effects Cell Survival/drug effects Cells, Cultured Endothelium, Vascular/cytology/drug effects/growth & development Enzyme Inhibitors/pharmacology Humans Phenanthrenes/pharmacology Poly(ADP-ribose) Polymerases/*antagonists & inhibitors Vascular Endothelial Growth Factor A/antagonists & inhibitors
Pubmed
Web of science
Create date
24/01/2008 18:01
Last modification date
20/08/2019 15:32
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