Long-term results of combined transepithelial phototherapeutic keratectomy and corneal collagen crosslinking for keratoconus: Cretan protocol.
Details
Serval ID
serval:BIB_752DA94983B7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term results of combined transepithelial phototherapeutic keratectomy and corneal collagen crosslinking for keratoconus: Cretan protocol.
Journal
Journal of cataract and refractive surgery
ISSN
1873-4502 (Electronic)
ISSN-L
0886-3350
Publication state
Published
Issued date
09/2014
Peer-reviewed
Oui
Volume
40
Number
9
Pages
1439-1445
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
To present the long-term results of combined transepithelial phototherapeutic keratectomy (PTK) and corneal collagen crosslinking (CXL) for keratoconus.
Vardinoyiannion Eye Institute of Crete, University of Crete, Heraklion, Crete, Greece.
Prospective case series.
Patients with progressive keratoconus had combined transepithelial PTK and CXL (Cretan protocol). Visual and refractive outcomes and the endothelial cell density (ECD) were evaluated preoperatively and postoperatively.
Twenty patients (23 eyes) were enrolled; postoperatively 23 eyes were evaluated at 1 and 2 years, 11 at 3 years, and 7 at 4 years. The mean follow-up was 33.83 months±10.82 (SD) (range 24 to 56 months). No intraoperative or postoperative complications occurred. The mean uncorrected distance visual acuity improved significantly from 0.99±0.57 logMAR preoperatively to 0.61±0.36 logMAR at the last follow-up (P<.001) and the mean corrected distance visual acuity, from 0.27±0.24 logMAR to 0.17±0.14 logMAR (P=.018), respectively. The mean steep and mean flat keratometry readings decreased significantly from 53.39±7.14 diopters (D) and 47.17±4.87 D, respectively, preoperatively to 49.99±4.36 D (P<.001) and 45.47±2.95 D (P=.002), respectively, at the last follow-up. The mean corneal astigmatism improved significantly from -6.27±4.19 D preoperatively to -4.52±2.80 D (P<.001) at the last follow-up. No significant ECD alterations occurred (P>.05).
Combined transepithelial PTK and CXL was effective and safe in keratoconic patients over a long-term follow-up.
No author has a financial or proprietary interest in any material or method mentioned.
Vardinoyiannion Eye Institute of Crete, University of Crete, Heraklion, Crete, Greece.
Prospective case series.
Patients with progressive keratoconus had combined transepithelial PTK and CXL (Cretan protocol). Visual and refractive outcomes and the endothelial cell density (ECD) were evaluated preoperatively and postoperatively.
Twenty patients (23 eyes) were enrolled; postoperatively 23 eyes were evaluated at 1 and 2 years, 11 at 3 years, and 7 at 4 years. The mean follow-up was 33.83 months±10.82 (SD) (range 24 to 56 months). No intraoperative or postoperative complications occurred. The mean uncorrected distance visual acuity improved significantly from 0.99±0.57 logMAR preoperatively to 0.61±0.36 logMAR at the last follow-up (P<.001) and the mean corrected distance visual acuity, from 0.27±0.24 logMAR to 0.17±0.14 logMAR (P=.018), respectively. The mean steep and mean flat keratometry readings decreased significantly from 53.39±7.14 diopters (D) and 47.17±4.87 D, respectively, preoperatively to 49.99±4.36 D (P<.001) and 45.47±2.95 D (P=.002), respectively, at the last follow-up. The mean corneal astigmatism improved significantly from -6.27±4.19 D preoperatively to -4.52±2.80 D (P<.001) at the last follow-up. No significant ECD alterations occurred (P>.05).
Combined transepithelial PTK and CXL was effective and safe in keratoconic patients over a long-term follow-up.
No author has a financial or proprietary interest in any material or method mentioned.
Keywords
Adolescent, Adult, Collagen/metabolism, Combined Modality Therapy, Corneal Stroma/metabolism, Cross-Linking Reagents, Epithelium, Corneal/surgery, Female, Follow-Up Studies, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Keratoconus/surgery, Keratoconus/therapy, Lasers, Excimer/therapeutic use, Male, Photochemotherapy/methods, Photorefractive Keratectomy/methods, Photosensitizing Agents/therapeutic use, Prospective Studies, Refraction, Ocular/physiology, Riboflavin/therapeutic use, Ultraviolet Rays, Visual Acuity/physiology, Young Adult
Pubmed
Web of science
Create date
30/09/2019 17:17
Last modification date
06/10/2019 6:26