Homocysteine as a risk factor for cardiovascular disease: should we (still) worry about?

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State: Public
Version: author
Serval ID
serval:BIB_752C7C97D18E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Homocysteine as a risk factor for cardiovascular disease: should we (still) worry about?
Journal
Swiss Medical Weekly
Author(s)
Faeh D., Chiolero A., Paccaud F.
ISSN
1424-7860 (Print)
ISSN-L
0036-7672
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
136
Number
47-48
Pages
745-756
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Cardiovascular disease (CVD) is the leading cause of death worldwide. CVD is causally related to "classical" risk factors such as elevated blood pressure, cholesterol, or glucose level and smoking. A causal role in the development of CVD is also suggested for numerous other factors, including an elevated plasma homocysteine concentration. Variation of homocysteinaemia is mainly due to genetic mutations and/or vitamin deficiency. The homocysteine concentration can be lowered with folate. Vitamin supplementation has thus been proposed in individuals with hyperhomocysteinaemia in order to reduce their CVD risk. On the other hand, population-based studies show little or no association between moderate hyperhomocysteinaemia and CVD risk. Nor has any randomised clinical trial clearly proven the efficacy of lowering the homocysteine concentration as a means of lowering the incidence of CVD. Hence at present it is inappropriate to recommend screening and treatment of hyperhomocysteinaemia in asymptomatic persons with or without other CVD risk. Until new evidence is available, clinicians should focus on better control of the "classical" risk factors for CVD.
Keywords
Biological Markers/blood, Cardiovascular Diseases/etiology, Cardiovascular Diseases/prevention & control, Evidence-Based Medicine, Homocysteine/blood, Humans, Hyperhomocysteinemia/complications, Mass Screening, Randomized Controlled Trials as Topic, Risk Factors, Uncertainty, Vitamin B Complex/therapeutic use
Pubmed
Web of science
Create date
04/03/2008 14:58
Last modification date
20/08/2019 14:32
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