Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON)

Details

Serval ID
serval:BIB_74F6BEC884E1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Positive contrast visualization of iron oxide-labeled stem cells using inversion-recovery with ON-resonant water suppression (IRON)
Journal
Magnetic Resonance in Medicine
Author(s)
Stuber M., Gilson W.D., Schar M., Kedziorek D.A., Hofmann L.V., Shah S., Vonken E.J., Bulte J.W., Kraitchman D.L.
ISSN
0740-3194
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
58
Number
5
Pages
1072-1077
Language
english
Notes
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Abstract
In proton magnetic resonance imaging (MRI) metallic substances lead to magnetic field distortions that often result in signal voids in the adjacent anatomic structures. Thus, metallic objects and superparamagnetic iron oxide (SPIO)-labeled cells appear as hypointense artifacts that obscure the underlying anatomy. The ability to illuminate these structures with positive contrast would enhance noninvasive MR tracking of cellular therapeutics. Therefore, an MRI methodology that selectively highlights areas of metallic objects has been developed. Inversion-recovery with ON-resonant water suppression (IRON) employs inversion of the magnetization in conjunction with a spectrally-selective on-resonant saturation prepulse. If imaging is performed after these prepulses, positive signal is obtained from off-resonant protons in close proximity to the metallic objects. The first successful use of IRON to produce positive contrast in areas of metallic spheres and SPIO-labeled stem cells in vitro and in vivo is presented.
Keywords
*Contrast Media, Ferric Compounds/*chemistry, Stem Cells/*chemistry, Water/chemistry
Pubmed
Web of science
Open Access
Yes
Create date
02/03/2010 16:04
Last modification date
20/08/2019 14:32
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