Interrelation of ST-segment depression during bicycle ergometry and extent of myocardial ischaemia by myocardial perfusion SPECT.

Details

Serval ID
serval:BIB_74EC40881821
Type
Article: article from journal or magazin.
Collection
Publications
Title
Interrelation of ST-segment depression during bicycle ergometry and extent of myocardial ischaemia by myocardial perfusion SPECT.
Journal
European journal of nuclear medicine and molecular imaging
Author(s)
Muzzarelli S., Pfisterer M.E., Müller-Brand J., Zellweger M.J.
ISSN
1619-7089 (Electronic)
ISSN-L
1619-7070
Publication state
Published
Issued date
11/2009
Peer-reviewed
Oui
Volume
36
Number
11
Pages
1842-1850
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The aim of this study was to compare ST-segment depression (STD) during bicycle ergometry and extent of myocardial ischaemia assessed by myocardial perfusion SPECT (MPS) in a large patient cohort.
Consecutive patients (n = 955) referred for MPS with bicycle ergometry and interpretable stress ECG were evaluated with respect to ECG and MPS findings of ischaemia. The maximal STD was recorded and exercise ECG was considered ischaemic if STD was horizontal or downsloping (>or=1 mm). MPS was interpreted using a 20-segment model with a scale of 0 to 4. A summed stress (SSS), summed rest (SRS) and summed difference score (SDS = SSS-SRS, e.g. extent of ischaemia) were derived. Ischaemia was defined as an SDS >or= 2.
An exercise-induced STD was present in 215 patients (22%) and myocardial ischaemia on MPS was present in 366 patients (38%). The extent of ST-segment depression and the number of ECG leads with significant STD were each strongly and significantly associated with increasing severity of ischaemia and the number of coronary territories involved (p < 0.01 for all correlations).
These data demonstrate a strong correlation between the extent of STD, number of ischaemic leads and severity of myocardial ischaemia as assessed by MPS during bicycle ergometry.
Keywords
Cohort Studies, Electrocardiography, Exercise Test, Female, Humans, Male, Middle Aged, Myocardial Ischemia/diagnostic imaging, Myocardial Ischemia/pathology, Myocardial Ischemia/physiopathology, Myocardial Perfusion Imaging, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Create date
15/11/2017 17:22
Last modification date
23/02/2024 15:09
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