Neoplastic Barrett's oesophagus and long-term follow-up after endoscopic therapy: complete histological eradication of Barrett associated with high-grade dysplasia significantly decreases neoplasia relapse.

Details

Serval ID
serval:BIB_74DBC0A2BFB9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Neoplastic Barrett's oesophagus and long-term follow-up after endoscopic therapy: complete histological eradication of Barrett associated with high-grade dysplasia significantly decreases neoplasia relapse.
Journal
Surgical endoscopy
Author(s)
Caillol F., Godat S., Autret A., Bories E., Pesenti C., Ratone J.P., Poizat F., Guiramand J., Delpero J.R., Giovannini M.
ISSN
1432-2218 (Electronic)
ISSN-L
0930-2794
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
30
Number
12
Pages
5410-5418
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Endotherapy (ET) has replaced surgery as the first-line treatment of high-grade dysplasia (HGD)/superficial ECA (ECAs) from Barrett's oesophagus (BO). However, long-term follow-up and predictive factors of relapse are not so well studied. The aim of the following study was to evaluate the efficiency of ET for treatment of HGD/ECAs and to determine factors of long-term efficiency.
ET procedures were manually reported and registered in a hospital data base from March 2000 to July 2010. Inclusion criteria were HGD/ECA on pre-resection biopsies, complete histological and sufficient oncological resection of HGD/ECAs, and complete macroscopic resection of metaplastic BO. Sixty patients (53 men, mean age = 65 years) were included.
Median follow-up was 66 months [range 42-80]. Complete eradication of residual histological metaplastic BO occurred in 29 patients (48 %). Relapse rate at 36 months was 16.6 % (n = 10) and was unchanged at 60 months of follow-up. There was only one relapse (3.4 %) in case of complete eradication of metaplastic BO and 9 (31 %) in case of incomplete eradication. In univaried and multi-varied analysis, complete eradication of metaplastic BO (p < 0.05) and BO length <5 cm (p < 0.05) were predictive of neoplastic BO non relapse. The length of BO remained a prognostic factor for disease-free survival (DFS). When these preponderant data were cancelled out in multi-varied analysis, complete eradication of BO was a prognostic factor for DFS (p < 0.05).
Complete histological eradication of BO by ET significantly decreases the rate of neoplasia relapse.
Keywords
Adult, Aged, Barrett Esophagus/pathology, Barrett Esophagus/surgery, Biopsy, Disease-Free Survival, Esophageal Neoplasms/pathology, Esophageal Neoplasms/surgery, Esophagoscopy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Recurrence, Local/pathology, Neoplasm Recurrence, Local/prevention & control, Precancerous Conditions/pathology, Precancerous Conditions/surgery, Prognosis, Retrospective Studies, Treatment Outcome, Barrett’s oesophagus, DHG, ECA, Endoscopic resection, Follow-up
Pubmed
Web of science
Create date
07/10/2019 15:34
Last modification date
01/11/2019 7:26
Usage data