The effect of tolterodine 4 and 8 mg on the heart rate variability in healthy subjects.

Details

Serval ID
serval:BIB_74C0FF33578F
Type
Article: article from journal or magazin.
Collection
Publications
Title
The effect of tolterodine 4 and 8 mg on the heart rate variability in healthy subjects.
Journal
World Journal of Urology
Author(s)
Schiffers M., Sauermann P., Schurch B., Mehnert U.
ISSN
1433-8726 (Electronic)
ISSN-L
0724-4983
Publication state
Published
Issued date
2010
Volume
28
Number
5
Pages
651-656
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
PURPOSE: To investigate the potential effect of tolterodine on the human heart rate variability (HRV). Oral antimuscarinic treatment for overactive bladder might significantly alter HRV, which is an important predictor for cardiac and all-cause mortality. Yet, little information exists regarding the influence of oral antimuscarinics on the HRV.
METHODS: Healthy female volunteers were randomly assigned to either placebo, tolterodine extended release (ER) 4 or 8 mg. Before and 4 h post treatment, a 10 min electrocardiogram (ECG) was recorded in supine position. Frequency domain and time domain analysis of both ECG measurements resulted in very low frequency (VLF), low frequency (LF), and high frequency (HF) data, the root mean square of differences of successive NN (= normal to normal, i.e. interval between two R-peaks) intervals (RMSSD), and the standard deviation of the NN intervals (SDNN).
RESULTS: Thirty subjects (mean age: 23.7 ± 2.3 years) were investigated. Placebo caused no significant HRV changes. Tolterodine 4 mg significantly increased heart rate (HR) and significantly decreased VLF. Tolterodine 8 mg significantly decreased HF, VLF, RMSSD and SDNN and significantly increased HR and LF/HF ratio. The changes observed with 4 mg were not significantly different versus placebo, but 8 mg significantly increased LF/HF as compared to placebo.
CONCLUSIONS: A single dose of 8 mg tolterodine ER, but not 4 mg seems to reduce resting HRV versus placebo in young healthy subjects. This might be particular relevant for patients with pre-existing cardiac conditions on daily overactive bladder drug treatment and should be further investigated in larger trials.
Keywords
Administration, Oral, Adult, Benzhydryl Compounds/administration & dosage, Benzhydryl Compounds/pharmacology, Cresols/administration & dosage, Cresols/pharmacology, Dose-Response Relationship, Drug, Electrocardiography, Female, Heart Rate/drug effects, Heart Rate/physiology, Humans, Muscarinic Antagonists/administration & dosage, Muscarinic Antagonists/pharmacology, Phenylpropanolamine/administration & dosage, Phenylpropanolamine/pharmacology, Supine Position, Urinary Bladder, Overactive/drug therapy
Pubmed
Web of science
Create date
05/11/2014 12:12
Last modification date
20/08/2019 14:32
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