Histopathologic assessment of hot-spot microvessel density and vascular patterns in glioblastoma: Poor observer agreement limits clinical utility as prognostic factors: a translational research project of the European Organization for Research and Treatment of Cancer Brain Tumor Group
Details
Serval ID
serval:BIB_749599384589
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Histopathologic assessment of hot-spot microvessel density and vascular patterns in glioblastoma: Poor observer agreement limits clinical utility as prognostic factors: a translational research project of the European Organization for Research and Treatment of Cancer Brain Tumor Group
Journal
Cancer
ISSN
0008-543X (Print)
Publication state
Published
Issued date
07/2006
Volume
107
Number
1
Pages
162-70
Notes
Journal Article --- Old month value: Jul 1
Abstract
BACKGROUND: Hot-spot microvessel density (MVD) and vascular patterns have been reported as histopathologic factors that influence prognosis in retrospective series of malignant gliomas. To investigate clinical utility, the authors systematically studied observer agreement on MVD and vascular patterns and the influence of repeatedly assessed data on patient outcomes in 2 independent glioblastoma series. METHODS: MVD and vascular patterns were assessed retrospectively by 5 observers in 1) a retrospectively compiled glioblastoma series that included 110 patients and 2) a glioblastoma series that included 233 patients who were treated within a randomized trial. MVD was determined in the field of greatest density ("hot-spot"). Predominantly classic or bizarre vascular patterns were determined by using a previously defined algorithm. RESULTS: Observer agreement on MVD was highly variable (range of kappa values, 0.464-0.901). The worst observer agreement was achieved when both the selection of hot-spots and MVD counts were performed independently. Survival analysis did not show a consistent association between repeatedly assessed MVD and patient outcome. Observer agreement on vascular patterns was poor (kappa = 0.297). Survival analysis did not show a consistent association between repeatedly assessed vascular patterns and patient outcome. CONCLUSIONS: Observer agreement on hot-spot MVD and vascular patterns in patients with glioblastoma was poor in independent assessments. MVD and vascular patterns were not associated consistently with patient outcome. Based on these findings, the authors concluded that poor observer agreement limits the clinical utility of histopathologically assessed hot-spot MVD and vascular patterns as prognostic factors in patients with glioblastoma. Improved methodologies for morphologic assessment of glioblastoma vascularization need to be identified.
Keywords
Cohort Studies
Diagnostic Errors/*statistics & numerical data
Europe
Glioblastoma/*blood supply/*diagnosis
Humans
Immunohistochemistry/methods/standards/*statistics & numerical data
Microcirculation/pathology
Observer Variation
Prognosis
Randomized Controlled Trials
Retrospective Studies
Societies, Medical
Survival Analysis
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:06
Last modification date
20/08/2019 15:32