Focal thyroid incidental uptake detected by ¹⁸F-fluorodeoxyglucose positron emission tomography. Meta-analysis on prevalence and malignancy risk.
Details
Serval ID
serval:BIB_749146F9688B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Focal thyroid incidental uptake detected by ¹⁸F-fluorodeoxyglucose positron emission tomography. Meta-analysis on prevalence and malignancy risk.
Journal
Nuklearmedizin. Nuclear medicine
ISSN
0029-5566 (Print)
ISSN-L
0029-5566
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
52
Number
4
Pages
130-136
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis
Publication Status: ppublish
Publication Status: ppublish
Abstract
To perform a meta-analysis of published data on the prevalence and risk of malignancy of focal thyroid incidental uptake (FTIs) detected by Fluorine-18-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/CT.
A comprehensive literature search of studies published up to and including December 2012 was performed. Pooled prevalence and malignancy risk of FTIs were calculated, including a sub-analysis for the geographic areas of origin of the studies.
34 studies including 215,057 patients were selected. Pooled prevalence of FTIs was 1.92% (95% confidence interval [95%CI]: 1.87-1.99%). Overall, 1522 FTIs underwent histopathology evaluation. Pooled risk of malignancy was 36.2% (95%CI: 33.8-38.6%), without significant differences among various geographic areas.
FTIs are observed in about 2% of 18F-FDG-PET or PET/CT scans and carry a significant risk of malignancy. Therefore, further investigation is warranted whenever FTIs are detected by 18F-FDG-PET or PET/CT.
A comprehensive literature search of studies published up to and including December 2012 was performed. Pooled prevalence and malignancy risk of FTIs were calculated, including a sub-analysis for the geographic areas of origin of the studies.
34 studies including 215,057 patients were selected. Pooled prevalence of FTIs was 1.92% (95% confidence interval [95%CI]: 1.87-1.99%). Overall, 1522 FTIs underwent histopathology evaluation. Pooled risk of malignancy was 36.2% (95%CI: 33.8-38.6%), without significant differences among various geographic areas.
FTIs are observed in about 2% of 18F-FDG-PET or PET/CT scans and carry a significant risk of malignancy. Therefore, further investigation is warranted whenever FTIs are detected by 18F-FDG-PET or PET/CT.
Keywords
Female, Fluorodeoxyglucose F18, Humans, Incidence, Incidental Findings, Male, Positron-Emission Tomography/statistics & numerical data, Radiopharmaceuticals, Risk Factors, Sex Distribution, Thyroid Neoplasms/diagnostic imaging, Thyroid Neoplasms/epidemiology
Pubmed
Web of science
Create date
20/08/2017 20:29
Last modification date
20/08/2019 15:32
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