Transient networks of spatio-temporal connectivity map communication pathways in brain functional systems.

Details

Serval ID
serval:BIB_74529BEF3B67
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transient networks of spatio-temporal connectivity map communication pathways in brain functional systems.
Journal
NeuroImage
Author(s)
Griffa A., Ricaud B., Benzi K., Bresson X., Daducci A., Vandergheynst P., Thiran J.P., Hagmann P.
ISSN
1095-9572 (Electronic)
ISSN-L
1053-8119
Publication state
Published
Issued date
15/07/2017
Peer-reviewed
Oui
Volume
155
Pages
490-502
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The study of brain dynamics enables us to characterize the time-varying functional connectivity among distinct neural groups. However, current methods suffer from the absence of structural connectivity information. We propose to integrate infra-slow neural oscillations and anatomical-connectivity maps, as derived from functional and diffusion MRI, in a multilayer-graph framework that captures transient networks of spatio-temporal connectivity. These networks group anatomically wired and temporary synchronized brain regions and encode the propagation of functional activity on the structural connectome. In a group of 71 healthy subjects, we find that these transient networks demonstrate power-law spatial and temporal size, globally organize into well-known functional systems and describe wave-like trajectories of activation across anatomically connected regions. Within the transient networks, activity propagates through polysynaptic paths that include selective ensembles of structural connections and differ from the structural shortest paths. In the light of the communication-through-coherence principle, the identified spatio-temporal networks could encode communication channels' selection and neural assemblies, which deserves further attention. This work contributes to the understanding of brain structure-function relationships by considering the time-varying nature of resting-state interactions on the axonal scaffold, and it offers a convenient framework to study large-scale communication mechanisms and functional dynamics.

Keywords
Adult, Brain/anatomy & histology, Brain/diagnostic imaging, Brain/physiology, Connectome/methods, Diffusion Magnetic Resonance Imaging/methods, Female, Humans, Male, Nerve Net/anatomy & histology, Nerve Net/diagnostic imaging, Nerve Net/physiology, Young Adult, Brain connectivity, Brain dynamics, Communication-through-coherence, Diffusion MRI, Multilayer network, Point-process, Resting-state fMRI, Spatio-temporal connectome, Temporal network
Pubmed
Web of science
Create date
25/04/2017 18:45
Last modification date
20/08/2019 14:32
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