Association study of the CFH Y402H polymorphism with Alzheimer's disease.

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Version: Final published version
License: Not specified
Serval ID
serval:BIB_744B3158BBC9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Association study of the CFH Y402H polymorphism with Alzheimer's disease.
Journal
Neurobiology of aging
Author(s)
Le Fur I., Laumet G., Richard F., Fievet N., Berr C., Rouaud O., Delcourt C., Amouyel P., Lambert J.C.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Publication state
Published
Issued date
01/2010
Peer-reviewed
Oui
Volume
31
Number
1
Pages
165-166
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Several reports indicated that Alzheimer's disease (AD) and age-related macular degeneration (AMD) may share similar genetic and pathological features. We postulated that the functional Y402H polymorphism within the CFH gene and unambiguously recognised as a major genetic determinant of AMD, may also be a risk factor of AD. We analysed the association of this polymorphism with the AD risk in both prospective and cross-sectional studies. We were not able to detect such an association whatever the studied population, suggesting that the CFH gene is not a genetic determinant of AD.
Keywords
Alzheimer Disease/genetics, Alzheimer Disease/metabolism, Alzheimer Disease/physiopathology, Complement Factor H/genetics, Cross-Sectional Studies, DNA Mutational Analysis, Gene Frequency/genetics, Genetic Association Studies/methods, Genetic Linkage/genetics, Genetic Markers/genetics, Genetic Predisposition to Disease/genetics, Genetic Testing, Genotype, Humans, Macular Degeneration/genetics, Macular Degeneration/metabolism, Macular Degeneration/physiopathology, Polymorphism, Genetic/genetics, Prospective Studies
Pubmed
Web of science
Create date
22/08/2024 21:26
Last modification date
23/08/2024 9:34
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