Association study of the CFH Y402H polymorphism with Alzheimer's disease.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_744B3158BBC9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association study of the CFH Y402H polymorphism with Alzheimer's disease.
Journal
Neurobiology of aging
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Publication state
Published
Issued date
01/2010
Peer-reviewed
Oui
Volume
31
Number
1
Pages
165-166
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Several reports indicated that Alzheimer's disease (AD) and age-related macular degeneration (AMD) may share similar genetic and pathological features. We postulated that the functional Y402H polymorphism within the CFH gene and unambiguously recognised as a major genetic determinant of AMD, may also be a risk factor of AD. We analysed the association of this polymorphism with the AD risk in both prospective and cross-sectional studies. We were not able to detect such an association whatever the studied population, suggesting that the CFH gene is not a genetic determinant of AD.
Keywords
Alzheimer Disease/genetics, Alzheimer Disease/metabolism, Alzheimer Disease/physiopathology, Complement Factor H/genetics, Cross-Sectional Studies, DNA Mutational Analysis, Gene Frequency/genetics, Genetic Association Studies/methods, Genetic Linkage/genetics, Genetic Markers/genetics, Genetic Predisposition to Disease/genetics, Genetic Testing, Genotype, Humans, Macular Degeneration/genetics, Macular Degeneration/metabolism, Macular Degeneration/physiopathology, Polymorphism, Genetic/genetics, Prospective Studies
Pubmed
Web of science
Create date
22/08/2024 21:26
Last modification date
23/08/2024 9:34
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