Genome-Wide Epigenomic Analyses in Patients With Nociceptive and Neuropathic Chronic Pain Subtypes Reveals Alterations in Methylation of Genes Involved in the Neuro-Musculoskeletal System.

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Version: Final published version
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Serval ID
serval:BIB_743ADE0A479C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-Wide Epigenomic Analyses in Patients With Nociceptive and Neuropathic Chronic Pain Subtypes Reveals Alterations in Methylation of Genes Involved in the Neuro-Musculoskeletal System.
Journal
The journal of pain
Author(s)
Stenz L., Carré J.L., Luthi F., Vuistiner P., Burrus C., Paoloni-Giacobino A., Léger B.
ISSN
1528-8447 (Electronic)
ISSN-L
1526-5900
Publication state
Published
Issued date
02/2022
Peer-reviewed
Oui
Volume
23
Number
2
Pages
326-336
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Nociceptive pain involves the activation of nociceptors without damage to the nervous system, whereas neuropathic pain is related to an alteration in the central or peripheral nervous system. Chronic pain itself and the transition from acute to chronic pain may be epigenetically controlled. In this cross-sectional study, a genome-wide DNA methylation analysis was performed using the blood DNA reduced representation bisulfite sequencing (RRBS) technique. Three prospective cohorts including 20 healthy controls (CTL), 18 patients with chronic nociceptive pain (NOCI), and 19 patients with chronic neuropathic pain (NEURO) were compared at both the single CpG and differentially methylated region (DMR) levels. Genes with DMRs were seen in the NOCI and NEURO groups belonged to the neuro-musculoskeletal system and differed between NOCI and NEURO patients. Our results demonstrate that the epigenetic disturbances accompanying nociceptive pain are very different from those accompanying neuropathic pain. In the former, among others, the epigenetic disturbance observed would affect the function of the opioid analgesic system, whereas in the latter it would affect that of the GABAergic reward system. This study presents biological findings that help to characterize NOCI- and NEURO-affected pathways and opens the possibility of developing epigenetic diagnostic assays. PERSPECTIVE: Our results help to explain the various biological pathways modifications underlying the different clinical manifestations of nociceptive and neuropathic pains. Furthermore, the new targets identified in our study might help to discover more specific treatments for nociceptive or neuropathic pains.
Keywords
Biomarkers, Chronic pain, DNA methylation, Neuropathic pain, Nociceptive pain, biomarkers, chronic pain, neuropathic pain, nociceptive pain
Pubmed
Web of science
Open Access
Yes
Create date
27/09/2021 9:51
Last modification date
16/04/2024 7:11
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