Prevalence and factors associated with cancer-related fatigue in Swiss adult survivors of childhood cancer.

Details

Serval ID
serval:BIB_743391448D43
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence and factors associated with cancer-related fatigue in Swiss adult survivors of childhood cancer.
Journal
Journal of cancer survivorship
Author(s)
Sláma T., Belle F.N., Strebel S., Christen S., Hägler-Laube E., Rössler J., Kuehni C.E., von der Weid N.X., Schindera C.
ISSN
1932-2267 (Electronic)
ISSN-L
1932-2259
Publication state
Published
Issued date
02/2024
Peer-reviewed
Oui
Volume
18
Number
1
Pages
135-143
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Reported prevalence of cancer-related fatigue (CRF) among childhood cancer survivors (CCS) varies widely, and evidence on factors associated with CRF among CCS is limited. We aimed to investigate the prevalence of CRF and its associated factors among adult CCS in Switzerland.
In a prospective cohort study, we invited adult CCS who survived at least 5 years since last cancer diagnosis, and were diagnosed when age 0-20 years and treated at Inselspital Bern between 1976 and 2015 to complete two fatigue-measuring instruments: the Checklist Individual Strength subjective fatigue subscale (CIS8R; increased fatigue 27-34, severe fatigue ≥ 35) and the numerical rating scale (NRS; moderate fatigue 4-6, severe fatigue 7-10). We collected information about previous cancer treatment and medical history, and calculated β coefficients for the association between CIS8R/NRS fatigue scores and potential determinants using multivariable linear regression.
We included 158 CCS (participation rate: 30%) with a median age at study of 33 years (interquartile range 26-38). Based on CIS8R, 19% (N = 30) of CCS reported increased fatigue, yet none reported severe fatigue. CRF was associated with female sex, central nervous system (CNS) tumors, sleep disturbance, and endocrine disorders. Lower CRF levels were observed among CCS age 30-39 years compared to those younger.
A considerable proportion of adult CCS reported increased levels of CRF.
CCS who are female and < 30 years old, have a history of CNS tumor, report sleep disturbance, or have an endocrine disorder should be screened for CRF.
Keywords
Adult, Humans, Child, Female, Infant, Newborn, Infant, Child, Preschool, Adolescent, Young Adult, Male, Neoplasms/complications, Neoplasms/epidemiology, Cancer Survivors, Prospective Studies, Prevalence, Switzerland/epidemiology, Fatigue/epidemiology, Fatigue/etiology, Childhood cancer, Fatigue, Late effects, Questionnaires, Survivors
Pubmed
Web of science
Open Access
Yes
Create date
15/06/2023 16:53
Last modification date
21/02/2024 7:16
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