The great migration: How glial cells could regulate GnRH neuron development and shape adult reproductive life.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_742D3A783B4B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The great migration: How glial cells could regulate GnRH neuron development and shape adult reproductive life.
Journal
Journal of chemical neuroanatomy
Author(s)
Duittoz A.H., Tillet Y., Geller S.
ISSN
1873-6300 (Electronic)
ISSN-L
0891-0618
Publication state
Published
Issued date
11/2022
Peer-reviewed
Oui
Volume
125
Pages
102149
Language
english
Notes
Publication types: Review ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
In mammals, reproductive function is under the control of hypothalamic neurons named Gonadotropin-Releasing Hormone (GnRH) neurons. These neurons migrate from the olfactory placode to the brain, during embryonic development. For the past 40 years, these neurons have been considered an example of tangential migration, i.e., dependent on the olfactory/vomeronasal/terminal nerves. Numerous studies have highlighted the factors involved in the migration of these neurons but thus far overlooked the cellular microenvironment that produces them. Many of these factors are dysregulated in hypogonadotropic hypogonadism, resulting in subfertility/infertility. Nevertheless, over the past ten years, several papers have reported the influence of glial cells (named olfactory ensheathing cells [OECs]) in the migration and differentiation of GnRH neurons. This review will describe the atypical origins, migration, and differentiation of these neurons, focusing on the latest discoveries. There will be a more specific discussion on the involvement of OECs in the development of GnRH neurons, during embryonic and perinatal life; as well as on their potential implication in the development of congenital or idiopathic hypogonadotropic hypogonadism (such as Kallmann syndrome).
Keywords
Animals, Adult, Humans, Gonadotropin-Releasing Hormone, Cell Movement/physiology, Neuroglia, Kallmann Syndrome, Neurons/physiology, Mammals, Glia, GnRH, HHG, Hypothalamus, LHRH, Neural crest, Olfactory ensheathing cells, Olfactory placode, Polycystic syndrome
Pubmed
Web of science
Open Access
Yes
Create date
13/09/2022 15:56
Last modification date
30/09/2023 7:12
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