Striatal D2 receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with 11C-raclopride and positron emission tomography.

Details

Serval ID
serval:BIB_7349886A7536
Type
Article: article from journal or magazin.
Collection
Publications
Title
Striatal D2 receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with 11C-raclopride and positron emission tomography.
Journal
Annals of Neurology
Author(s)
Brooks D.J., Ibanez V., Sawle G.V., Playford E.D., Quinn N., Mathias C.J., Lees A.J., Marsden C.D., Bannister R., Frackowiak R.S.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Publication state
Published
Issued date
1992
Volume
31
Number
2
Pages
184-192
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Equilibrium striatal: cerebellar 11C-raclopride (RAC) uptake ratios reflect the density of striatal dopamine D2 binding sites. Using positron emission tomographic scanning we have measured striatal RAC uptake in 6 untreated patients with Parkinson's disease (PD), 5 chronically treated patients with PD and a fluctuating response to L-dopa, 10 patients with striatonigral degeneration (SND), and 9 patients with progressive supranuclear palsy (PSP). Regional cerebral blood flow was determined also, with C15O2. Mean striatal: cerebellar RAC uptake was not significantly different from normal in untreated patients with PD, though 2 of these 6 patients showed significantly increased putamen tracer binding. Mean caudate and putamen: cerebellar RAC uptake ratios of the group with PD and a fluctuating response to L-dopa were significantly reduced by 30% and 18%, respectively. The patients with SND had lesser, but significant, 10% and 11% decreases in mean caudate and putamen: cerebellar RAC uptake ratios, respectively, whereas patients with PSP showed 24% and 9% reductions in caudate and putamen: cerebellar RAC binding. Striatal and frontal blood flow were significantly reduced in patients with PSP, but not in patients with PD or SND. In conclusion, striatal D2 binding potential is normal or raised in untreated patients with PD, but reduced in patients with PD and a fluctuating response to L-dopa. Patients with SND and PSP show a decrease in striatal RAC binding, but to a lesser extent than patients with PD and a fluctuating response to treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Adult, Aged, Caudate Nucleus/metabolism, Caudate Nucleus/radionuclide imaging, Corpus Striatum/metabolism, Corpus Striatum/radionuclide imaging, Humans, Levodopa/pharmacology, Levodopa/therapeutic use, Middle Aged, Nerve Degeneration, Parkinson Disease/drug therapy, Parkinson Disease/metabolism, Putamen/metabolism, Putamen/radionuclide imaging, Raclopride, Receptors, Dopamine/analysis, Receptors, Dopamine/drug effects, Salicylamides/diagnostic use, Salicylamides/pharmacokinetics, Substantia Nigra/metabolism, Substantia Nigra/radionuclide imaging, Supranuclear Palsy, Progressive/metabolism, Supranuclear Palsy, Progressive/radionuclide imaging, Tomography, Emission-Computed
Pubmed
Web of science
Create date
25/09/2011 16:29
Last modification date
20/08/2019 14:31
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