Decreased Left Caudate Volume Is Associated with Increased Severity of Autistic-Like Symptoms in a Cohort of ADHD Patients and Their Unaffected Siblings.

Details

Ressource 1Download: journal.pone.0165620.PDF (2000.15 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_7335D0E61810
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Decreased Left Caudate Volume Is Associated with Increased Severity of Autistic-Like Symptoms in a Cohort of ADHD Patients and Their Unaffected Siblings.
Journal
PloS one
Author(s)
O'Dwyer L., Tanner C., van Dongen E.V., Greven C.U., Bralten J., Zwiers M.P., Franke B., Heslenfeld D., Oosterlaan J., Hoekstra P.J., Hartman C.A., Groen W., Rommelse N., Buitelaar J.K.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
11
Number
11
Pages
e0165620
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Autism spectrum disorder (ASD) symptoms frequently occur in individuals with attention-deficit/hyperactivity disorder (ADHD). While there is evidence that both ADHD and ASD have differential structural brain correlates, knowledge of the structural brain profile of individuals with ADHD with raised ASD symptoms is limited. The presence of ASD-like symptoms was measured by the Children's Social Behavior Questionnaire (CSBQ) in a sample of typically developing controls (n = 154), participants with ADHD (n = 239), and their unaffected siblings (n = 144) between the ages of 8 and 29. Structural magnetic resonance imaging (MRI) correlates of ASD ratings were analysed by studying the relationship between ASD ratings and grey matter volumes using mixed effects models which controlled for ADHD symptom count and total brain volume. ASD ratings were significantly elevated in participants with ADHD relative to controls and unaffected siblings. For the entire group (participants with ADHD, unaffected siblings and TD controls), mixed effect models revealed that the left caudate nucleus volume was negatively correlated with ASD ratings (t = 2.83; P = 0.005). The current findings are consistent with the role of the caudate nucleus in executive function, including the selection of goals based on the evaluation of action outcomes and the use of social reward to update reward representations. There is a specific volumetric profile associated with subclinical ASD-like symptoms in participants with ADHD, unaffected siblings and controls with the caudate nucleus and globus pallidus being of critical importance in predicting the level of ASD-like symptoms in all three groups.

Keywords
Adolescent, Adult, Attention Deficit Disorder with Hyperactivity/complications, Attention Deficit Disorder with Hyperactivity/diagnostic imaging, Attention Deficit Disorder with Hyperactivity/psychology, Autism Spectrum Disorder/diagnostic imaging, Autism Spectrum Disorder/epidemiology, Autism Spectrum Disorder/psychology, Brain Mapping, Caudate Nucleus/pathology, Child, Cohort Studies, Female, Gray Matter/diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Siblings/psychology, Surveys and Questionnaires, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
28/11/2016 13:01
Last modification date
20/08/2019 14:31
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