Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality.

Details

Serval ID
serval:BIB_73352493345A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality.
Journal
Annals of Medicine
Author(s)
Rüegg C., Zaric J., Stupp R.
ISSN
0785-3890 (Print)
ISSN-L
0785-3890
Publication state
Published
Issued date
2003
Volume
35
Number
7
Pages
476-487
Language
english
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase (COX)-2, are therapeutic groups widely used for the treatment of pain, inflammation and fever. There is growing experimental and clinical evidence indicating NSAIDs and COX-2 inhibitors also have anti-cancer activity. Epidemiological studies have shown that regular use of Aspirin and other NSAIDs reduces the risk of developing cancer, in particular of the colon. Molecular pathology studies have revealed that COX-2 is expressed by cancer cells and cells of the tumor stroma during tumor progression and in response to chemotherapy or radiotherapy. Experimental studies have demonstrated that COX-2 over expression promotes tumorigenesis, and that NSAIDs and COX-2 inhibitors suppress tumorigenesis and tumor progression. Clinical trials have shown that NSAIDs and COX-2 inhibitors suppress colon polyp formation and malignant progression in patients with familial adenomatous polyposis (FAP) syndrome. Recent advances in the understanding of the cellular and molecular mechanisms of the anti-cancer effects of NSAIDs and COX-2 inhibitors have demonstrated that these drugs target both tumor cells and the tumor vasculature. The therapeutic benefits of COX-2 inhibitors in the treatment of human cancer in combination with chemotherapy or radiotherapy are currently being tested in clinical trials. In this article we will review recent advances in the understanding of the anti-tumor mechanisms of these drugs and discuss their potential application in clinical oncology.
Keywords
Angiogenesis Inhibitors, Animals, Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Anti-Inflammatory Agents, Non-Steroidal/pharmacology, Antineoplastic Agents/therapeutic use, Cyclooxygenase 2, Disease Progression, Humans, Isoenzymes/antagonists & inhibitors, Membrane Proteins, Neoplasms/drug therapy, Neoplasms/enzymology, Neovascularization, Pathologic/drug therapy, Prostaglandin-Endoperoxide Synthases
Pubmed
Web of science
Create date
28/01/2008 9:36
Last modification date
20/08/2019 15:31
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