Demography and natural selection have shaped genetic variation in Drosophila melanogaster: a multi-locus approach.

Details

Serval ID
serval:BIB_72EDFBC26A86
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Demography and natural selection have shaped genetic variation in Drosophila melanogaster: a multi-locus approach.
Journal
Genetics
Author(s)
Glinka S., Ometto L., Mousset S., Stephan W., De Lorenzo D.
ISSN
0016-6731
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
165
Number
3
Pages
1269-1278
Language
english
Abstract
Demography and selection have been recognized for their important roles in shaping patterns of nucleotide variability. To investigate the relative effects of these forces in the genome of Drosophila melanogaster, we used a multi-locus scan (105 fragments) of X-linked DNA sequence variation in a putatively ancestral African and a derived European population. Surprisingly, we found evidence for a recent size expansion in the African population, i.e., a significant excess of singletons at a chromosome-wide level. In the European population, such an excess was not detected. In contrast to the African population, we found evidence for positive natural selection in the European sample: (i) a large number of loci with low levels of variation and (ii) a significant excess of derived variants at the low-variation loci that are fixed in the European sample but rare in the African population. These results are consistent with the hypothesis that the European population has experienced frequent selective sweeps in the recent past during its adaptation to new habitats. Our study shows the advantages of a genomic approach (over a locus-specific analysis) in disentangling demographic and selective forces.
Keywords
Animals, Drosophila melanogaster/genetics, Polymerase Chain Reaction, Polymorphism, Genetic, Recombination, Genetic, Selection (Genetics), X Chromosome
Pubmed
Web of science
Create date
19/11/2007 10:33
Last modification date
20/08/2019 14:31
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