IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.

Details

Serval ID
serval:BIB_72BA2B267468
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Létourneau S., van Leeuwen E.M., Krieg C., Martin C., Pantaleo G., Sprent J., Surh C.D., Boyman O.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
2010
Volume
107
Number
5
Pages
2171-2176
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
IL-2 is crucial to T cell homeostasis, especially of CD4(+) T regulatory cells and memory CD8(+) cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor alpha (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis.
Keywords
Animals, Antibodies, Blocking/administration & dosage, Antigen-Antibody Complex/metabolism, Half-Life, Homeostasis, Immunoglobulin G/metabolism, Interleukin-2/immunology, Interleukin-2/metabolism, Interleukin-2 Receptor alpha Subunit/antagonists & inhibitors, Interleukin-2 Receptor alpha Subunit/deficiency, Mice, Mice, Congenic, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Receptors, Fc/metabolism, Recombinant Fusion Proteins/immunology, Recombinant Fusion Proteins/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
23/02/2010 14:58
Last modification date
20/08/2019 14:30
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