Diabetes mellitus and cancer risk in a network of case-control studies.

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State: Public
Version: author
Serval ID
serval:BIB_72B700DF3FA2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diabetes mellitus and cancer risk in a network of case-control studies.
Journal
Nutrition and Cancer
Author(s)
Bosetti C., Rosato V., Polesel J., Levi F., Talamini R., Montella M., Negri E., Tavani A., Zucchetto A., Franceschi S., Corrao G., La Vecchia C.
ISSN
1532-7914 (Electronic)
ISSN-L
0163-5581
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
64
Number
5
Pages
643-651
Language
english
Notes
Publication types: Journal Article
Abstract
Diabetes has been associated to the risk of a few cancer sites, though quantification of this association in various populations remains open to discussion. We analyzed the relation between diabetes and the risk of various cancers in an integrated series of case-control studies conducted in Italy and Switzerland between 1991 and 2009. The studies included 1,468 oral and pharyngeal, 505 esophageal, 230 gastric, 2,390 colorectal, 185 liver, 326 pancreatic, 852 laryngeal, 3,034 breast, 607 endometrial, 1,031 ovarian, 1,294 prostate, and 767 renal cell cancer cases and 12,060 hospital controls. The multivariate odds ratios (OR) for subjects with diabetes as compared to those without-adjusted for major identified confounding factors for the cancers considered through logistic regression models-were significantly elevated for cancers of the oral cavity/pharynx (OR = 1.58), esophagus (OR = 2.52), colorectum (OR = 1.23), liver (OR = 3.52), pancreas (OR = 3.32), postmenopausal breast (OR = 1.76), and endometrium (OR = 1.70). For cancers of the oral cavity, esophagus, colorectum, liver, and postmenopausal breast, the excess risk persisted over 10 yr since diagnosis of diabetes. Our data confirm and further quantify the association of diabetes with colorectal, liver, pancreatic, postmenopausal breast, and endometrial cancer and suggest forthe first time that diabetes may also increase the risk of oral/pharyngeal and esophageal cancer. [Table: see text] [Table: see text].
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Web of science
Create date
27/04/2012 7:28
Last modification date
20/08/2019 14:30
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