Enhanced and aberrant T cell trafficking following total body irradiation: a gateway to graft-versus-host disease?

Details

Serval ID
serval:BIB_7298164B0162
Type
Article: article from journal or magazin.
Collection
Publications
Title
Enhanced and aberrant T cell trafficking following total body irradiation: a gateway to graft-versus-host disease?
Journal
British Journal of Haematology
Author(s)
Vianello F., Cannella L., Coe D., Chai J.G., Golshayan D., Marelli-Berg F.M., Dazzi F.
ISSN
1365-2141 (Electronic)
ISSN-L
0007-1048
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
162
Number
6
Pages
808-818
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. pdf type: research paper
Abstract
Pre-transplant conditioning regimens play a major role in triggering graft-versus-host disease (GVHD). This study investigated the effect of irradiation on donor T cell trafficking to lymphoid and non-lymphoid tissues by comparing the migration of carboxy-fluorescein diacetate succinimidyl ester-labelled, naïve donor T lymphocytes in vivo in irradiated and non-irradiated syngeneic mice recipients. Recruitment of adoptively transferred naïve T cells to secondary lymphoid organs was increased in irradiated mice and naïve T cells also aberrantly localized to non-lymphoid tissues. Irradiation also induced aberrant effector memory T cell migration into lymph nodes and their localization to homing-privileged non-lymphoid sites, such as the gut. The presence of a minor histocompatibility mismatch further enhanced the aberrant accumulation of T cells in both lymphoid and non-lymphoid tissue, whilst their migratory pattern was not modified as compared to fully matched irradiated recipients. These effects correlated with decreased permeability of, and the secretion of chemotactic factors by the endothelium. Our findings are consistent with the possibility that excessive, dysregulated extravasation of T cells induced by irradiation promotes the development of GVHD.
Pubmed
Open Access
Yes
Create date
10/02/2014 11:06
Last modification date
20/08/2019 14:30
Usage data