Binding and activation properties of angiotensin II in dispersed rat anterior pituitary cells

Details

Serval ID
serval:BIB_727BE62C469E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Binding and activation properties of angiotensin II in dispersed rat anterior pituitary cells
Journal
Endocrinology
Author(s)
Capponi  A. M., Favrod-Coune  C. A., Gaillard  R. C., Muller  A. F.
ISSN
0013-7227 (Print)
Publication state
Published
Issued date
03/1982
Volume
110
Number
3
Pages
1043-5
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
The properties of angiotensin II receptors were studied in isolated rat anterior pituitary cells prepared by trypsin digestion. Angiotensin II bound in a time- and temperature-dependent manner to pituitary cells, with Kd of 4.1 x 10(-9) M. The heptapeptide, des-Asp1-angiotensin II, had only one-tenth of the affinity of the octapeptide (Ki = 5.5 x 10(-8) M). These two peptides displayed a similar potency ratio in their ability to stimulate ACTH release from pituitary cells. These results indicate that angiotensin II may play a regulatory role in controlling ACTH secretion from the pituitary gland.
Keywords
Angiotensin II/*metabolism/pharmacology Animals Binding, Competitive Female Kinetics Pituitary Gland, Anterior/drug effects/*metabolism Rats Rats, Inbred Strains Receptors, Angiotensin/*metabolism Receptors, Cell Surface/*metabolism
Pubmed
Web of science
Create date
15/02/2008 17:57
Last modification date
03/03/2018 18:17
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